Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion
Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis of the internal environment in patients with chronic diseases. The effects of NP contamination on health in chronically ill populations must urgently be elucidated. In this study, NPs injected via the tail vein were distribu...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000478 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590969869959168 |
|---|---|
| author | Lu Wang Jia-Qi Ma Li-Jia Song Xiao-Peng Qu Yue Zhang Hai-Ming Fan Chao Wang Long-Long Zheng Guo-Dong Gao Yan Qu Liang-Liang Shen Bei Liu |
| author_facet | Lu Wang Jia-Qi Ma Li-Jia Song Xiao-Peng Qu Yue Zhang Hai-Ming Fan Chao Wang Long-Long Zheng Guo-Dong Gao Yan Qu Liang-Liang Shen Bei Liu |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis of the internal environment in patients with chronic diseases. The effects of NP contamination on health in chronically ill populations must urgently be elucidated. In this study, NPs injected via the tail vein were distributed in the brain and internal organs in a mouse model of chronic internal carotid occlusion. Mice with chronic internal carotid artery occlusion exposed to NPs showed behavioral abnormalities, such as depression and anxiety, thus indicating detrimental effects of NPs on the brain. Subsequently, we used proteomics and metabolomics to analyze the specific mechanisms underlying the damaging effects of NP deposition in the brain. The findings helped explain the differences in the underlying biochemical responses at the microscopic level in mice after NP exposure. The NPs not only accumulated in the brain and caused pathologic damage, but also contributed to accelerating atherosclerosis in the mouse model of internal carotid artery occlusion. This work confirms the risk of NPs in a model of internal carotid artery occlusion and elucidates the mechanism underlying this harm; moreover, it provides theoretical support for developing strategies to decrease microplastic intake in patients with internal carotid artery occlusion. |
| format | Article |
| id | doaj-art-95f24abfd2c44cb6bb45e4c3a55066d6 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-95f24abfd2c44cb6bb45e4c3a55066d62025-01-23T05:26:11ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117711Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusionLu Wang0Jia-Qi Ma1Li-Jia Song2Xiao-Peng Qu3Yue Zhang4Hai-Ming Fan5Chao Wang6Long-Long Zheng7Guo-Dong Gao8Yan Qu9Liang-Liang Shen10Bei Liu11Department of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Pediatrics, Tangdu Hospital, Airforce Military Medical University, Xi'an, ChinaDepartment of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, ChinaKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an 710127, ChinaDepartment of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, ChinaDepartment of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, China; Corresponding authors.Department of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, China; Corresponding authors.Department of Biochemistry and Molecular Biology, Basic Medical Science Academy, Airforce Military Medical University, Xi'an, China; Corresponding authors.Department of Neurosurgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, Shaanxi, China; Correspondence to: Department of Biochemistry and Molecular Biology, Basic Medical Science Academy, Airforce Military Medical University, Xi'an, Shaanxi, China.Accumulation of nanoplastics (NPs) poses a severe threat to the homeostasis of the internal environment in patients with chronic diseases. The effects of NP contamination on health in chronically ill populations must urgently be elucidated. In this study, NPs injected via the tail vein were distributed in the brain and internal organs in a mouse model of chronic internal carotid occlusion. Mice with chronic internal carotid artery occlusion exposed to NPs showed behavioral abnormalities, such as depression and anxiety, thus indicating detrimental effects of NPs on the brain. Subsequently, we used proteomics and metabolomics to analyze the specific mechanisms underlying the damaging effects of NP deposition in the brain. The findings helped explain the differences in the underlying biochemical responses at the microscopic level in mice after NP exposure. The NPs not only accumulated in the brain and caused pathologic damage, but also contributed to accelerating atherosclerosis in the mouse model of internal carotid artery occlusion. This work confirms the risk of NPs in a model of internal carotid artery occlusion and elucidates the mechanism underlying this harm; moreover, it provides theoretical support for developing strategies to decrease microplastic intake in patients with internal carotid artery occlusion.http://www.sciencedirect.com/science/article/pii/S0147651325000478NPsInternal carotid artery occlusionBrain injuryAtherosclerosisProteomics and Metabolomics |
| spellingShingle | Lu Wang Jia-Qi Ma Li-Jia Song Xiao-Peng Qu Yue Zhang Hai-Ming Fan Chao Wang Long-Long Zheng Guo-Dong Gao Yan Qu Liang-Liang Shen Bei Liu Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion Ecotoxicology and Environmental Safety NPs Internal carotid artery occlusion Brain injury Atherosclerosis Proteomics and Metabolomics |
| title | Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion |
| title_full | Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion |
| title_fullStr | Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion |
| title_full_unstemmed | Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion |
| title_short | Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion |
| title_sort | comprehensive multi omics behavioral and morphological analysis of the hazards of nano plastics in mice with internal carotid artery occlusion |
| topic | NPs Internal carotid artery occlusion Brain injury Atherosclerosis Proteomics and Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000478 |
| work_keys_str_mv | AT luwang comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT jiaqima comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT lijiasong comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT xiaopengqu comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT yuezhang comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT haimingfan comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT chaowang comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT longlongzheng comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT guodonggao comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT yanqu comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT liangliangshen comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion AT beiliu comprehensivemultiomicsbehavioralandmorphologicalanalysisofthehazardsofnanoplasticsinmicewithinternalcarotidarteryocclusion |