Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema
Spinal cord injury (SCI) is an incapacitating condition that affects motor, sensory, and autonomic functions. Since 1990, the only treatment administered in the acute phase of SCI has been methylprednisolone (MP), a synthetic corticosteroid that has anti-inflammatory effects; however, its efficacy r...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/4792932 |
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| author | Eibar Ernesto Cabrera-Aldana Fernando Ruelas Cristina Aranda Ruth Rincon-Heredia Angelina Martínez-Cruz Alejandro Reyes-Sánchez Gabriel Guizar-Sahagún Luis B. Tovar-y-Romo |
| author_facet | Eibar Ernesto Cabrera-Aldana Fernando Ruelas Cristina Aranda Ruth Rincon-Heredia Angelina Martínez-Cruz Alejandro Reyes-Sánchez Gabriel Guizar-Sahagún Luis B. Tovar-y-Romo |
| author_sort | Eibar Ernesto Cabrera-Aldana |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is an incapacitating condition that affects motor, sensory, and autonomic functions. Since 1990, the only treatment administered in the acute phase of SCI has been methylprednisolone (MP), a synthetic corticosteroid that has anti-inflammatory effects; however, its efficacy remains controversial. Although MP has been thought to help in the resolution of edema, there are no scientific grounds to support this assertion. Aquaporin 4 (AQP4), the most abundant component of water channels in the CNS, participates in the formation and elimination of edema, but it is not clear whether the modulation of AQP4 expression by MP plays any role in the physiopathology of SCI. We studied the functional expression of AQP4 modulated by MP following SCI in an experimental model in rats along with the associated changes in the permeability of the blood-spinal cord barrier. We analyzed these effects in male and female rats and found that SCI increased AQP4 expression in the spinal cord white matter and that MP diminished such increase to baseline levels. Moreover, MP increased the extravasation of plasma components after SCI and enhanced tissue swelling and edema. Our results lend scientific support to the increasing motion to avoid MP treatment after SCI. |
| format | Article |
| id | doaj-art-95f0e4f6851f438ab4c833465aa57bff |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-95f0e4f6851f438ab4c833465aa57bff2025-08-20T03:20:34ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/47929324792932Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates EdemaEibar Ernesto Cabrera-Aldana0Fernando Ruelas1Cristina Aranda2Ruth Rincon-Heredia3Angelina Martínez-Cruz4Alejandro Reyes-Sánchez5Gabriel Guizar-Sahagún6Luis B. Tovar-y-Romo7Spine Surgery Service, National Rehabilitation Institute, Mexico City, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, MexicoDepartment of Experimental Surgery, Proyecto Camina A.C., Mexico City, MexicoSpine Surgery Service, National Rehabilitation Institute, Mexico City, MexicoResearch Unit for Neurological Diseases, Instituto Mexicano del Seguro Social, Mexico City, MexicoDivisión de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, MexicoSpinal cord injury (SCI) is an incapacitating condition that affects motor, sensory, and autonomic functions. Since 1990, the only treatment administered in the acute phase of SCI has been methylprednisolone (MP), a synthetic corticosteroid that has anti-inflammatory effects; however, its efficacy remains controversial. Although MP has been thought to help in the resolution of edema, there are no scientific grounds to support this assertion. Aquaporin 4 (AQP4), the most abundant component of water channels in the CNS, participates in the formation and elimination of edema, but it is not clear whether the modulation of AQP4 expression by MP plays any role in the physiopathology of SCI. We studied the functional expression of AQP4 modulated by MP following SCI in an experimental model in rats along with the associated changes in the permeability of the blood-spinal cord barrier. We analyzed these effects in male and female rats and found that SCI increased AQP4 expression in the spinal cord white matter and that MP diminished such increase to baseline levels. Moreover, MP increased the extravasation of plasma components after SCI and enhanced tissue swelling and edema. Our results lend scientific support to the increasing motion to avoid MP treatment after SCI.http://dx.doi.org/10.1155/2017/4792932 |
| spellingShingle | Eibar Ernesto Cabrera-Aldana Fernando Ruelas Cristina Aranda Ruth Rincon-Heredia Angelina Martínez-Cruz Alejandro Reyes-Sánchez Gabriel Guizar-Sahagún Luis B. Tovar-y-Romo Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema Mediators of Inflammation |
| title | Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema |
| title_full | Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema |
| title_fullStr | Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema |
| title_full_unstemmed | Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema |
| title_short | Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema |
| title_sort | methylprednisolone administration following spinal cord injury reduces aquaporin 4 expression and exacerbates edema |
| url | http://dx.doi.org/10.1155/2017/4792932 |
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