Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C Markers
Hepatitis C virus (HCV), which was identified in 1989 - 1990. Later it was included in new genus Hepacivirus of the family Flaviviridae. Due the genetic heterogeneity of HCV, viral isolates was decided to classificate on genotypes and sybtypes in accordance with the sequence of nucleotides in a cert...
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Numikom LLC
2015-06-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/53 |
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| author | L. I. Nikolaeva E. A. Leybman G. V. Sapronov |
| author_facet | L. I. Nikolaeva E. A. Leybman G. V. Sapronov |
| author_sort | L. I. Nikolaeva |
| collection | DOAJ |
| description | Hepatitis C virus (HCV), which was identified in 1989 - 1990. Later it was included in new genus Hepacivirus of the family Flaviviridae. Due the genetic heterogeneity of HCV, viral isolates was decided to classificate on genotypes and sybtypes in accordance with the sequence of nucleotides in a certain area of the genome. It was discover that the virus infect only human and chimpanzee. Modern molecular epidemiological data, obtained after 2000, indicate monocentric origin of HCV from Africa, most likely from the central part. Probably, in Africa the conditions for feeling HCV-like virus from unknown non-primate mammal to human were formed. Recently HCV-like viruses were found in dogs, horses, bars, and rodents. The most common hypothesis of the HCV origin base on unknown virus, which is belong to genus Hepacivirus and does not infect human-like primate. The virus is included into group of nonprimate hepacivirus (NPHV). In last centure in our country viral intergenotype recombinant RF_2k/1b was appeared. In modern time HCV diversity can appeared as serology poor displayed forms of the virus. Drug-resistant variants of HCV can accumulate and disseminate again the background of antiviral therapy. |
| format | Article |
| id | doaj-art-95edab235c414d28be3c7fbda0eceffd |
| institution | DOAJ |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2015-06-01 |
| publisher | Numikom LLC |
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| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-95edab235c414d28be3c7fbda0eceffd2025-08-20T03:01:26ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942015-06-01143233010.31631/2073-3046-2015-14-3-23-3052Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C MarkersL. I. Nikolaeva0E. A. Leybman1G. V. Sapronov2Federal Budgetary State Istablishment «Federal State Research Centre of Epidemiology and Microbiology named by N.F. Gamaley» of the Russian Ministry of HealthcareFederal Budgetary State Istablishment «Federal State Research Centre of Epidemiology and Microbiology named by N.F. Gamaley» of the Russian Ministry of Healthcare, State Educational Institute of Higher Professional Training of the Ministry of Healthcare of the Russian Federation «Russian National Research Medical University named by N.I. Pirogov»State Budgetary Educational Institution for Additional Higher Professional Training «Russian Medical Academy of Post-Graduate Education»Hepatitis C virus (HCV), which was identified in 1989 - 1990. Later it was included in new genus Hepacivirus of the family Flaviviridae. Due the genetic heterogeneity of HCV, viral isolates was decided to classificate on genotypes and sybtypes in accordance with the sequence of nucleotides in a certain area of the genome. It was discover that the virus infect only human and chimpanzee. Modern molecular epidemiological data, obtained after 2000, indicate monocentric origin of HCV from Africa, most likely from the central part. Probably, in Africa the conditions for feeling HCV-like virus from unknown non-primate mammal to human were formed. Recently HCV-like viruses were found in dogs, horses, bars, and rodents. The most common hypothesis of the HCV origin base on unknown virus, which is belong to genus Hepacivirus and does not infect human-like primate. The virus is included into group of nonprimate hepacivirus (NPHV). In last centure in our country viral intergenotype recombinant RF_2k/1b was appeared. In modern time HCV diversity can appeared as serology poor displayed forms of the virus. Drug-resistant variants of HCV can accumulate and disseminate again the background of antiviral therapy.https://www.epidemvac.ru/jour/article/view/53вирус гепатита спроисхождениеизменчивостьрезистентные варианты вирусаhepatitis c virusorigindiversityviral resistant variants |
| spellingShingle | L. I. Nikolaeva E. A. Leybman G. V. Sapronov Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C Markers Эпидемиология и вакцинопрофилактика вирус гепатита с происхождение изменчивость резистентные варианты вируса hepatitis c virus origin diversity viral resistant variants |
| title | Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C Markers |
| title_full | Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C Markers |
| title_fullStr | Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C Markers |
| title_full_unstemmed | Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C Markers |
| title_short | Evolution and Diversity of Hepatitis C Virus and Peculiarity of Modern Laboratory Diagnostic of Hepatitis C Markers |
| title_sort | evolution and diversity of hepatitis c virus and peculiarity of modern laboratory diagnostic of hepatitis c markers |
| topic | вирус гепатита с происхождение изменчивость резистентные варианты вируса hepatitis c virus origin diversity viral resistant variants |
| url | https://www.epidemvac.ru/jour/article/view/53 |
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