Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli
Aim of investigation. To study pathogenic mechanisms and morphological signs of rectal mucosa reparation after rectal mucosectomy and application of cellbased biotechnologies at surgical treatment of familial adenomatosis coli (FAC).Material and methods. The new method of FAC surgical treatment whic...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2013-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1250 |
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| author | Ye. A. Kogan D. V. Vyshegorodtsev N. M. Faizullina T. A. Demura A. M. Kuzminov Yu. A. Shelygin G. T. Sukhikh |
| author_facet | Ye. A. Kogan D. V. Vyshegorodtsev N. M. Faizullina T. A. Demura A. M. Kuzminov Yu. A. Shelygin G. T. Sukhikh |
| author_sort | Ye. A. Kogan |
| collection | DOAJ |
| description | Aim of investigation. To study pathogenic mechanisms and morphological signs of rectal mucosa reparation after rectal mucosectomy and application of cellbased biotechnologies at surgical treatment of familial adenomatosis coli (FAC).Material and methods. The new method of FAC surgical treatment which provides preservation of part of the mucosa-deprived rectum is presented. For reconstruction of mucosa of the rectum cell-based allotransplantation was applied. Morphological mechanisms of mucosal reparation were investigated in 34 FAC patients (main and control groups).Results. The reparation of mucosa in demucosated rectum at application of cell-based transplantation develops in shorter terms in comparison to control group. It is carried out by largeintestinal, smallintestinal types, by squamous cell differentiation and by combination of all types. At reparation cells with signs of stem cells take part.Conclusions. Original method can be applied for treatment of FAC as it delays polyps and rectal cancer development for many years. |
| format | Article |
| id | doaj-art-95ed78632c6c4e6b93473a950785d056 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2013-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-95ed78632c6c4e6b93473a950785d0562025-02-10T16:14:33ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732013-12-012367379833Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coliYe. A. Kogan0D. V. Vyshegorodtsev1N. M. Faizullina2T. A. Demura3A. M. Kuzminov4Yu. A. Shelygin5G. T. Sukhikh6Federal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian FederationFederal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian FederationFederal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian FederationFederal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian FederationFederal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian FederationFederal state-funded institution «State Scientific Center of Coloproctology» Ministry of heathcare of the Russian FederationFederal state-funded institution «Kulakov Federal Center on Obstetrics, Gynecology and Perinatology» Ministry of heathcare of the Russian FederationAim of investigation. To study pathogenic mechanisms and morphological signs of rectal mucosa reparation after rectal mucosectomy and application of cellbased biotechnologies at surgical treatment of familial adenomatosis coli (FAC).Material and methods. The new method of FAC surgical treatment which provides preservation of part of the mucosa-deprived rectum is presented. For reconstruction of mucosa of the rectum cell-based allotransplantation was applied. Morphological mechanisms of mucosal reparation were investigated in 34 FAC patients (main and control groups).Results. The reparation of mucosa in demucosated rectum at application of cell-based transplantation develops in shorter terms in comparison to control group. It is carried out by largeintestinal, smallintestinal types, by squamous cell differentiation and by combination of all types. At reparation cells with signs of stem cells take part.Conclusions. Original method can be applied for treatment of FAC as it delays polyps and rectal cancer development for many years.https://www.gastro-j.ru/jour/article/view/1250familial adenomatosis coli, cell-based transplantation, mesenchyma, intestinal epithelium |
| spellingShingle | Ye. A. Kogan D. V. Vyshegorodtsev N. M. Faizullina T. A. Demura A. M. Kuzminov Yu. A. Shelygin G. T. Sukhikh Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli Российский журнал гастроэнтерологии, гепатологии, колопроктологии familial adenomatosis coli, cell-based transplantation, mesenchyma, intestinal epithelium |
| title | Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli |
| title_full | Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli |
| title_fullStr | Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli |
| title_full_unstemmed | Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli |
| title_short | Morphological aspects of cell-based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli |
| title_sort | morphological aspects of cell based reconstruction of rectal mucosa at surgical treatment of familial adenomatosis coli |
| topic | familial adenomatosis coli, cell-based transplantation, mesenchyma, intestinal epithelium |
| url | https://www.gastro-j.ru/jour/article/view/1250 |
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