The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells

The Pregnane-X receptor regulates steroid synthesis in mouse Leydig cells

IntroductionPregnane X Receptor (PXR, NR1I2) is a ligand-dependent transcription factor belonging to the nuclear receptor superfamily, that can be activated by a wide variety of endogenous and exogenous ligands. It is a major actor of the endo- and xeno-biotic detoxification process. It also regulat...

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Bibliographic Details
Main Authors: Emmanuelle Martinot, Hélène Holota, Angélique de Haze, Claude Beaudoin, David H. Volle
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Endocrinology
Subjects:
PXR
testosterone
Leydig cells
mouse
xenobiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1430781/full
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