Drug-induced psoriasis

Psoriasis is known to be triggered by a number of factors including drugs. Some therapeutic agents for the treatment of psoriasis are also known to have a paradoxical effect and alter the course of the disease. The drugs may either cause de novo psoriasis or are responsible for aggravating preexisti...

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Main Authors: Sunil Dogra, Divya Kamat
Format: Article
Language:English
Published: SAGE Publishing 2019-01-01
Series:Indian Journal of Rheumatology
Subjects:
Online Access:http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=37;epage=43;aulast=Dogra
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author Sunil Dogra
Divya Kamat
author_facet Sunil Dogra
Divya Kamat
author_sort Sunil Dogra
collection DOAJ
description Psoriasis is known to be triggered by a number of factors including drugs. Some therapeutic agents for the treatment of psoriasis are also known to have a paradoxical effect and alter the course of the disease. The drugs may either cause de novo psoriasis or are responsible for aggravating preexisting psoriasis. The distinction is not always clear-cut and is clinically often indistinguishable from psoriasis vulgaris. The morphological types can vary from plaque psoriasis to pustular psoriasis and even erythroderma. There are certain established agents which are known to trigger psoriasis. Many of the biological agents and targeted therapies available today can trigger psoriasis by activating signaling pathways. The lag time between the intake of drug and onset of psoriasis is highly variable and thus requires a high index of suspicion. Due to the various systemic comorbidities, patients with psoriasis often receive polypharmacy and hence it is important for dermatologists, rheumatologists, and physicians to be aware of the possible triggers.
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publishDate 2019-01-01
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series Indian Journal of Rheumatology
spelling doaj-art-95e98ba4a6594f8284e47bcae5c491602025-02-02T23:09:23ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012019-01-01145374310.4103/0973-3698.272159Drug-induced psoriasisSunil DograDivya KamatPsoriasis is known to be triggered by a number of factors including drugs. Some therapeutic agents for the treatment of psoriasis are also known to have a paradoxical effect and alter the course of the disease. The drugs may either cause de novo psoriasis or are responsible for aggravating preexisting psoriasis. The distinction is not always clear-cut and is clinically often indistinguishable from psoriasis vulgaris. The morphological types can vary from plaque psoriasis to pustular psoriasis and even erythroderma. There are certain established agents which are known to trigger psoriasis. Many of the biological agents and targeted therapies available today can trigger psoriasis by activating signaling pathways. The lag time between the intake of drug and onset of psoriasis is highly variable and thus requires a high index of suspicion. Due to the various systemic comorbidities, patients with psoriasis often receive polypharmacy and hence it is important for dermatologists, rheumatologists, and physicians to be aware of the possible triggers.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=37;epage=43;aulast=Dogradrug triggereddrug-inducedpsoriasis
spellingShingle Sunil Dogra
Divya Kamat
Drug-induced psoriasis
Indian Journal of Rheumatology
drug triggered
drug-induced
psoriasis
title Drug-induced psoriasis
title_full Drug-induced psoriasis
title_fullStr Drug-induced psoriasis
title_full_unstemmed Drug-induced psoriasis
title_short Drug-induced psoriasis
title_sort drug induced psoriasis
topic drug triggered
drug-induced
psoriasis
url http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2019;volume=14;issue=5;spage=37;epage=43;aulast=Dogra
work_keys_str_mv AT sunildogra druginducedpsoriasis
AT divyakamat druginducedpsoriasis