Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation Disorders
Managing drug-resistant tuberculosis (MDR-TB) in patients with underlying coagulation disorders such as hemophilia and combined factor V and VIII deficiency presents significant challenges due to the risk of bleeding and potential drug-related complications. This case series details two unique insta...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2025-02-01
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| Series: | Indian Journal of Respiratory Care |
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| Online Access: | https://www.ijrc.in/doi/IJRC/pdf/10.5005/jp-journals-11010-1148 |
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| author | Raghul Raj S |
| author_facet | Raghul Raj S |
| author_sort | Raghul Raj S |
| collection | DOAJ |
| description | Managing drug-resistant tuberculosis (MDR-TB) in patients with underlying coagulation disorders such as hemophilia and combined factor V and VIII deficiency presents significant challenges due to the risk of bleeding and potential drug-related complications. This case series details two unique instances of MDR-TB in such patients, exploring the complexities of treatment. Tuberculosis, known to induce a hypercoagulable state, can further complicate existing coagulation abnormalities. Using individualized shorter all-oral MDR-TB regimens alongside careful monitoring, both patients were successfully treated without severe bleeding episodes or deterioration in their coagulation profiles. This series highlights the importance of therapeutic approaches with close interdisciplinary collaboration to manage such cases effectively and improve patient outcomes. |
| format | Article |
| id | doaj-art-95e7b9140ceb4bb89324873a76d64e5d |
| institution | OA Journals |
| issn | 2277-9019 2321-4899 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Respiratory Care |
| spelling | doaj-art-95e7b9140ceb4bb89324873a76d64e5d2025-08-20T02:16:45ZengJaypee Brothers Medical PublisherIndian Journal of Respiratory Care2277-90192321-48992025-02-0113426526710.5005/jp-journals-11010-114811Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation DisordersRaghul Raj S0Raghul Raj S, Department of Respiratory Medicine, Velammal Medical College Hospital and Research Institute, Madurai, Tamil Nadu, India, Phone: +91 7598305440Managing drug-resistant tuberculosis (MDR-TB) in patients with underlying coagulation disorders such as hemophilia and combined factor V and VIII deficiency presents significant challenges due to the risk of bleeding and potential drug-related complications. This case series details two unique instances of MDR-TB in such patients, exploring the complexities of treatment. Tuberculosis, known to induce a hypercoagulable state, can further complicate existing coagulation abnormalities. Using individualized shorter all-oral MDR-TB regimens alongside careful monitoring, both patients were successfully treated without severe bleeding episodes or deterioration in their coagulation profiles. This series highlights the importance of therapeutic approaches with close interdisciplinary collaboration to manage such cases effectively and improve patient outcomes.https://www.ijrc.in/doi/IJRC/pdf/10.5005/jp-journals-11010-1148case reportcoagulation disorderscombined factors v and viii deficiencyhemophiliamultidrug resistant tuberculosis |
| spellingShingle | Raghul Raj S Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation Disorders Indian Journal of Respiratory Care case report coagulation disorders combined factors v and viii deficiency hemophilia multidrug resistant tuberculosis |
| title | Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation Disorders |
| title_full | Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation Disorders |
| title_fullStr | Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation Disorders |
| title_full_unstemmed | Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation Disorders |
| title_short | Challenges and Triumphs: A Case Series of Drug-resistant Tuberculosis Management in Patients with Coagulation Disorders |
| title_sort | challenges and triumphs a case series of drug resistant tuberculosis management in patients with coagulation disorders |
| topic | case report coagulation disorders combined factors v and viii deficiency hemophilia multidrug resistant tuberculosis |
| url | https://www.ijrc.in/doi/IJRC/pdf/10.5005/jp-journals-11010-1148 |
| work_keys_str_mv | AT raghulrajs challengesandtriumphsacaseseriesofdrugresistanttuberculosismanagementinpatientswithcoagulationdisorders |