Comprehensive prognostic gene identification and functional characterization of GRAMD1A in Wilms tumor: development of risk prediction models and therapeutic implications

Comprehensive prognostic gene identification and functional characterization of GRAMD1A in Wilms tumor: development of risk prediction models and therapeutic implications

BackgroundWilms tumor (WT) is the most common pediatric kidney cancer, with survival rates exceeding 90% in localized cases. However, advanced or recurrent WT remains difficult to treat due to poor prognosis and limited knowledge of its molecular mechanisms. Gene expression profiling has shown promi...

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Bibliographic Details
Main Authors: Qiang Zeng, Junfeng Tao, Lilu Qin, Yong Zeng, Zhong Liu, Mingxian Xu, Linshan Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Oncology
Subjects:
Wilms tumor
GRAMD1A
prognostic markers
LASSO regression
cell cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1501718/full
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