Clinical description of adults with eosinophilic esophagitis treated at a Chilean university center
Introduction and aim: Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease that affects the esophagus. Its epidemiology in Chile and Latin America is unknown due to the absence of population studies. Our aim was to describe the clinical, endoscopic, and histologic charact...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Revista de Gastroenterología de México (English Edition) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255534X2500009X |
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| Summary: | Introduction and aim: Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease that affects the esophagus. Its epidemiology in Chile and Latin America is unknown due to the absence of population studies. Our aim was to describe the clinical, endoscopic, and histologic characteristics of adult patients diagnosed with EoE, as well as their treatment response. Material and methods: A descriptive prospective study was conducted on a cohort of patients ≥ 18 years of age with an eosinophil count greater than 15 eosinophils/high power field. Results: A total of 62 patients were included, 75.8% of whom were men. Mean patient age was 38 years, mean age at diagnosis was 34 years, and diagnosis was made later in men. Sixty-five percent had a concomitant immunoallergic disease, and allergic rhinitis was the most frequent. Dysphagia was the most frequent referral, with a predominance of men. Women presented more often with food allergies and peripheral eosinophilia. The most frequent endoscopic finding was edema, followed by rings, with a mean eosinophilic esophagitis endoscopic reference score (EREFS) of 3.5 and a mean eosinophil count in biopsies of 37.5 eosinophils/high power field. Men presented with a higher EREFS and eosinophil count at diagnosis. All patients received treatment and the most frequent was with proton pump inhibitors, followed by combination treatment with corticosteroids. Endoscopic (partial/total) and histologic response rates were 93.5 and 77%, respectively. Conclusion: We found characteristics in our cohort similar to those described in international groups. Women presented with greater autoimmune comorbidity, peripheral eosinophilia, and food allergies, but had a lower eosinophil count and endoscopic score. We found no differences between the different therapeutic regimens. Resumen: Introducción y objetivo: La esofagitis eosinofílica (EEo) es una enfermedad inflamatoria crónica inmunomediada que afecta al esófago. En Chile y Latinoamérica se desconoce su epidemiología debido a la ausencia de estudios poblacionales. El objetivo de es describir características clínicas, endoscópicas e histológicas de pacientes adultos con el diagnóstico de EEo, así como la respuesta al tratamiento. Material y metodos: Estudio descriptivo prospectivo de cohorte pacientes ≥ 18 años con recuento mayor a 15 eosinófilos/campo. Resultados: 62 pacientes, 75,8% hombres edad promedio 38 años, edad promedio al diagnóstico 34 años, siendo más tardío en hombres; 65% tenía otra enfermedad inmunoalérgica concomitante, siendo más frecuente rinitis alérgica. El motivo de consulta más frecuente fue disfagia, predominando en hombres. Mujeres presentaron mayor frecuencia de alergias alimentarias y eosinofilia periférica. El hallazgo endoscópico más frecuente fue edema seguido de anillos con un puntaje EREFS (Eosinophilic Esophagitis Endoscopic Reference Score) promedio de 3,5 y un recuento promedio de eosinófilos en biopsias de 37,5 eosinófilos/campo. Hombres presentaron EREFS y recuento de eosinófilos más altos al diagnóstico. Todos los pacientes recibieron tratamiento, siendo lo más frecuente el uso de inhibidores de la bomba protones seguido por tratamiento combinado con corticoides. La tasa de respuesta endoscópica (parcial/total) e histológica fue 93,5% y 77% respectivamente. Conclusión: En esta cohorte, observamos características similares a lo descrito en grupos internacionales. Las mujeres presentaron mayor comorbilidad autoinmune, eosinofilia periférica y alergias alimentarias pero un menor recuento de eosinófilos y score endoscópico. No observamos diferencias entre los distintos esquemas terapéuticos. |
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| ISSN: | 2255-534X |