Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy
Exosomal circular RNA (circRNAs) are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids posit...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Pharmaceutical Analysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177924001643 |
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| author | Xi Li Hanzhe Liu Peiyu Xing Tian Li Yi Fang Shuang Chen Siyuan Dong |
| author_facet | Xi Li Hanzhe Liu Peiyu Xing Tian Li Yi Fang Shuang Chen Siyuan Dong |
| author_sort | Xi Li |
| collection | DOAJ |
| description | Exosomal circular RNA (circRNAs) are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids positions them as potential non-invasive biomarkers, revealing the molecular dynamics of cancers. Research in exosomal circRNAs is reshaping our understanding of neoplastic intercellular communication. Exploiting the natural properties of exosomes for targeted drug delivery and disrupting circRNA-mediated pro-tumorigenic signaling can develop new treatment modalities. Therefore, ongoing exploration of exosomal circRNAs in cancer research is poised to revolutionize clinical management of cancer. This emerging field offers hope for significant breakthroughs in cancer care. This review underscores the critical role of exosomal circRNAs in cancer biology and drug resistance, highlighting their potential as non-invasive biomarkers and therapeutic targets that could transform the clinical management of cancer. |
| format | Article |
| id | doaj-art-95dcfb7ab0394c3b90576060a66133f4 |
| institution | Kabale University |
| issn | 2095-1779 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj-art-95dcfb7ab0394c3b90576060a66133f42025-01-31T05:11:13ZengElsevierJournal of Pharmaceutical Analysis2095-17792025-02-01152101067Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapyXi Li0Hanzhe Liu1Peiyu Xing2Tian Li3Yi Fang4Shuang Chen5Siyuan Dong6Department of Vascular and Thyroid Surgery, The First Hospital of China Medical University, Shenyang, 110001, ChinaDepartment of Critical Care Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, ChinaDepartment of Ophthalmology, China Medical University the Fourth People's Hospital of Shenyang, Shenyang, 110031, ChinaSchool of Basic Medicine, The Fourth Military Medical University, Xi'an, 710032, ChinaDepartment of Ultrasound, The First Hospital of China Medical University, Shenyang, 110001, ChinaDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, 110001, China; Corresponding author.Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, 110001, China; Corresponding author.Exosomal circular RNA (circRNAs) are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids positions them as potential non-invasive biomarkers, revealing the molecular dynamics of cancers. Research in exosomal circRNAs is reshaping our understanding of neoplastic intercellular communication. Exploiting the natural properties of exosomes for targeted drug delivery and disrupting circRNA-mediated pro-tumorigenic signaling can develop new treatment modalities. Therefore, ongoing exploration of exosomal circRNAs in cancer research is poised to revolutionize clinical management of cancer. This emerging field offers hope for significant breakthroughs in cancer care. This review underscores the critical role of exosomal circRNAs in cancer biology and drug resistance, highlighting their potential as non-invasive biomarkers and therapeutic targets that could transform the clinical management of cancer.http://www.sciencedirect.com/science/article/pii/S2095177924001643Exosomal circRNAsTumor microenvironmentCancer biomarkers |
| spellingShingle | Xi Li Hanzhe Liu Peiyu Xing Tian Li Yi Fang Shuang Chen Siyuan Dong Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy Journal of Pharmaceutical Analysis Exosomal circRNAs Tumor microenvironment Cancer biomarkers |
| title | Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy |
| title_full | Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy |
| title_fullStr | Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy |
| title_full_unstemmed | Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy |
| title_short | Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy |
| title_sort | exosomal circrnas deciphering the novel drug resistance roles in cancer therapy |
| topic | Exosomal circRNAs Tumor microenvironment Cancer biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2095177924001643 |
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