Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure
Abstract Infection‐induced bone defects present significant challenges in clinical bone regeneration, frequently leading to poor bone induction, recurring infections, and complications such as pain and chronic inflammation. This study introduces a novel Ti/Lignin‐Ag@PLL composite coating with a “san...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-12-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202400164 |
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| author | Yushuang Guan Guoming Zou Henigul osman Dong Zhang Tianyou Zhou Wenguo Cui Yingbo Wang |
| author_facet | Yushuang Guan Guoming Zou Henigul osman Dong Zhang Tianyou Zhou Wenguo Cui Yingbo Wang |
| author_sort | Yushuang Guan |
| collection | DOAJ |
| description | Abstract Infection‐induced bone defects present significant challenges in clinical bone regeneration, frequently leading to poor bone induction, recurring infections, and complications such as pain and chronic inflammation. This study introduces a novel Ti/Lignin‐Ag@PLL composite coating with a “sandwich” structure, designed to integrate pro‐adhesion, photothermal‐photodynamic antibacterial, and osteogenic properties. The Ti/Lignin‐Ag@PLL composite coating is fabricated using self‐assembly technology, in which Ag+ is reduced to silver nanoparticles (Ag‐NPs) by lignin, followed by Polylysine (PLL) grafting. Photothermal conversion efficiency is evaluated under near‐infrared (NIR) laser irradiation, while antibacterial activity is tested against E. coli and S. aureus. Biocompatibility is also assessed using vascular endothelial cells (VECs) and osteoblasts (OBs). The results indicate that the Ti/Lignin‐Ag@PLL coating demonstrates a 31% photothermal conversion efficiency and nearly 100% antibacterial efficacy against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) under NIR irradiation for 10 min. Without irradiation, the antibacterial rates are 85% and 94%, respectively, after 24 h. Additionally, the coating significantly promotes cell adhesion, proliferation, and osteogenesis, as evidenced by the upregulation of Runx2 and Collagen I. This study uniquely contributes to the development of a multifunctional composite coating that effectively combines robust antibacterial properties with enhanced osteogenic potential, offering a promising solution for bone tissue repair and infection prevention. |
| format | Article |
| id | doaj-art-95dbffd4db554478a8d6cc0140352dd5 |
| institution | OA Journals |
| issn | 2196-7350 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-95dbffd4db554478a8d6cc0140352dd52025-08-20T02:32:12ZengWiley-VCHAdvanced Materials Interfaces2196-73502024-12-011136n/an/a10.1002/admi.202400164Bone‐Induced Nanocomposite Coating with a “Sandwich” StructureYushuang Guan0Guoming Zou1Henigul osman2Dong Zhang3Tianyou Zhou4Wenguo Cui5Yingbo Wang6College of Chemical Engineering Xinjiang Normal University 102 Xinyi Road Urumqi 830054 P. R. ChinaCollege of Chemical Engineering Xinjiang Normal University 102 Xinyi Road Urumqi 830054 P. R. ChinaCollege of Chemical Engineering Xinjiang Normal University 102 Xinyi Road Urumqi 830054 P. R. ChinaCollege of Chemical Engineering Xinjiang Normal University 102 Xinyi Road Urumqi 830054 P. R. ChinaCollege of Control Engineering Xinjiang Institute of Engineering 1350 Aidinghu Road Urumqi 830023 P. R. ChinaDepartment of Orthopaedics, Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaCollege of Chemical Engineering Xinjiang Normal University 102 Xinyi Road Urumqi 830054 P. R. ChinaAbstract Infection‐induced bone defects present significant challenges in clinical bone regeneration, frequently leading to poor bone induction, recurring infections, and complications such as pain and chronic inflammation. This study introduces a novel Ti/Lignin‐Ag@PLL composite coating with a “sandwich” structure, designed to integrate pro‐adhesion, photothermal‐photodynamic antibacterial, and osteogenic properties. The Ti/Lignin‐Ag@PLL composite coating is fabricated using self‐assembly technology, in which Ag+ is reduced to silver nanoparticles (Ag‐NPs) by lignin, followed by Polylysine (PLL) grafting. Photothermal conversion efficiency is evaluated under near‐infrared (NIR) laser irradiation, while antibacterial activity is tested against E. coli and S. aureus. Biocompatibility is also assessed using vascular endothelial cells (VECs) and osteoblasts (OBs). The results indicate that the Ti/Lignin‐Ag@PLL coating demonstrates a 31% photothermal conversion efficiency and nearly 100% antibacterial efficacy against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) under NIR irradiation for 10 min. Without irradiation, the antibacterial rates are 85% and 94%, respectively, after 24 h. Additionally, the coating significantly promotes cell adhesion, proliferation, and osteogenesis, as evidenced by the upregulation of Runx2 and Collagen I. This study uniquely contributes to the development of a multifunctional composite coating that effectively combines robust antibacterial properties with enhanced osteogenic potential, offering a promising solution for bone tissue repair and infection prevention.https://doi.org/10.1002/admi.202400164adhesionbone inductioncomposite coatingphotothermal‐photodynamic antibacterialtitanium metal |
| spellingShingle | Yushuang Guan Guoming Zou Henigul osman Dong Zhang Tianyou Zhou Wenguo Cui Yingbo Wang Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure Advanced Materials Interfaces adhesion bone induction composite coating photothermal‐photodynamic antibacterial titanium metal |
| title | Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure |
| title_full | Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure |
| title_fullStr | Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure |
| title_full_unstemmed | Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure |
| title_short | Bone‐Induced Nanocomposite Coating with a “Sandwich” Structure |
| title_sort | bone induced nanocomposite coating with a sandwich structure |
| topic | adhesion bone induction composite coating photothermal‐photodynamic antibacterial titanium metal |
| url | https://doi.org/10.1002/admi.202400164 |
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