Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individuals
Abstract Objective We aimed to identify risk factors for hospital admission and severe disease among fully vaccinated (FV) individuals with COVID‐19. Further, we investigated if risk factors for hospitalization and severe disease are similar between unvaccinated (UV) and vaccinated individuals. Meth...
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Elsevier
2022-08-01
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| Series: | Journal of the American College of Emergency Physicians Open |
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| Online Access: | https://doi.org/10.1002/emp2.12793 |
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| author | Steven Johnson Nicholas Mielke Trini Mathew Gabriel N Maine Nai‐Wei Chen Amit Bahl |
| author_facet | Steven Johnson Nicholas Mielke Trini Mathew Gabriel N Maine Nai‐Wei Chen Amit Bahl |
| author_sort | Steven Johnson |
| collection | DOAJ |
| description | Abstract Objective We aimed to identify risk factors for hospital admission and severe disease among fully vaccinated (FV) individuals with COVID‐19. Further, we investigated if risk factors for hospitalization and severe disease are similar between unvaccinated (UV) and vaccinated individuals. Methods This was a multicenter, observational cohort analysis from a large regional healthcare system in metro Detroit using electronic health record data to evaluate risk factors for hospitalization and severe COVID‐19 disease. Vaccination data were retrieved using electronic medical records linked to our statewide immunization database. Consecutive adult FV and UV patients with a primary admission diagnosis of COVID‐19 were included in the comparative analysis. Partially vaccinated patients and patients who had received a booster dose were excluded. The primary outcome of this study was hospital admission and severe disease inclusive of intensive care unit (ICU) admission, mechanical ventilation, or death. Results Between December 15, 2020 and December 19, 2021, 20,584 emergency department visits met our inclusion criteria. Among these, 2005 (9.7%) visits consisted of FV individuals, 18,579 (90.3%) were UV, and 40.3% of UV and 52.7% of FV required hospitalization with similar (12.7% and 12.6%, respectively) rates of severe disease. Hospitalized UV patients with severe disease were younger than their FV counterparts (49.5% <65 years vs. 13.5% p < 0.001). Risk factors for severe disease on UV and FV included age ≥65 years (UV: adjusted odds ratio [aOR] 1.49, 95% confidence interval [CI] 1.28–1.73, p < 0.001 and FV: aOR 2.50, 95% CI 1.44–4.36 p = 0.001) and weighted Elixhauser score >10 (UV: aOR 9.11, 95% CI 6.92–12.00, p < 0.001 and FV: aOR 6.04, 95% CI 2.68–13.26, p < 0.001). However, only on UV status, body mass index (BMI) ≥30 kg/m2 was associated with increased odds of severe disease (aOR 2.59, 95% CI 2.09–3.22, p < 0.001). Conclusions FV patients with breakthrough SARS‐CoV‐2 infection who require hospitalization and have severe disease are older and have more medical comorbidities compared to UV patients. When comparing risk factors for severe disease between UV and FV individuals, FV status is particularly associated with reduced risk among patients with a BMI ≥30 kg/m2 and a moderate number of medical comorbidities, regardless of age, highlighting the importance of vaccination in these particularly vulnerable groups. |
| format | Article |
| id | doaj-art-95daff7364a84630833ae9c6f8435aac |
| institution | DOAJ |
| issn | 2688-1152 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the American College of Emergency Physicians Open |
| spelling | doaj-art-95daff7364a84630833ae9c6f8435aac2025-08-20T03:19:43ZengElsevierJournal of the American College of Emergency Physicians Open2688-11522022-08-0134n/an/a10.1002/emp2.12793Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individualsSteven Johnson0Nicholas Mielke1Trini Mathew2Gabriel N Maine3Nai‐Wei Chen4Amit Bahl5Department of Emergency Medicine Beaumont Hospital Royal Oak USAOakland University, William Beaumont School of Medicine Royal Oak USADepartment of Infectious Disease Beaumont Hospital Royal Oak USAHistocompatibility Laboratory Beaumont Hospital Royal Oak USABeaumont Hospital Royal Oak USADepartment of Emergency Medicine Beaumont Hospital Royal Oak USAAbstract Objective We aimed to identify risk factors for hospital admission and severe disease among fully vaccinated (FV) individuals with COVID‐19. Further, we investigated if risk factors for hospitalization and severe disease are similar between unvaccinated (UV) and vaccinated individuals. Methods This was a multicenter, observational cohort analysis from a large regional healthcare system in metro Detroit using electronic health record data to evaluate risk factors for hospitalization and severe COVID‐19 disease. Vaccination data were retrieved using electronic medical records linked to our statewide immunization database. Consecutive adult FV and UV patients with a primary admission diagnosis of COVID‐19 were included in the comparative analysis. Partially vaccinated patients and patients who had received a booster dose were excluded. The primary outcome of this study was hospital admission and severe disease inclusive of intensive care unit (ICU) admission, mechanical ventilation, or death. Results Between December 15, 2020 and December 19, 2021, 20,584 emergency department visits met our inclusion criteria. Among these, 2005 (9.7%) visits consisted of FV individuals, 18,579 (90.3%) were UV, and 40.3% of UV and 52.7% of FV required hospitalization with similar (12.7% and 12.6%, respectively) rates of severe disease. Hospitalized UV patients with severe disease were younger than their FV counterparts (49.5% <65 years vs. 13.5% p < 0.001). Risk factors for severe disease on UV and FV included age ≥65 years (UV: adjusted odds ratio [aOR] 1.49, 95% confidence interval [CI] 1.28–1.73, p < 0.001 and FV: aOR 2.50, 95% CI 1.44–4.36 p = 0.001) and weighted Elixhauser score >10 (UV: aOR 9.11, 95% CI 6.92–12.00, p < 0.001 and FV: aOR 6.04, 95% CI 2.68–13.26, p < 0.001). However, only on UV status, body mass index (BMI) ≥30 kg/m2 was associated with increased odds of severe disease (aOR 2.59, 95% CI 2.09–3.22, p < 0.001). Conclusions FV patients with breakthrough SARS‐CoV‐2 infection who require hospitalization and have severe disease are older and have more medical comorbidities compared to UV patients. When comparing risk factors for severe disease between UV and FV individuals, FV status is particularly associated with reduced risk among patients with a BMI ≥30 kg/m2 and a moderate number of medical comorbidities, regardless of age, highlighting the importance of vaccination in these particularly vulnerable groups.https://doi.org/10.1002/emp2.12793COVID‐19hospitalizationimmunizationmortalityrisk factorssevere disease |
| spellingShingle | Steven Johnson Nicholas Mielke Trini Mathew Gabriel N Maine Nai‐Wei Chen Amit Bahl Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individuals Journal of the American College of Emergency Physicians Open COVID‐19 hospitalization immunization mortality risk factors severe disease |
| title | Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individuals |
| title_full | Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individuals |
| title_fullStr | Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individuals |
| title_full_unstemmed | Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individuals |
| title_short | Predictors of hospitalization and severe disease due to breakthrough SARS‐CoV‐2 infection in fully vaccinated individuals |
| title_sort | predictors of hospitalization and severe disease due to breakthrough sars cov 2 infection in fully vaccinated individuals |
| topic | COVID‐19 hospitalization immunization mortality risk factors severe disease |
| url | https://doi.org/10.1002/emp2.12793 |
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