Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising Approach
TRIP13 is a member of the large AAA+ ATPase protein superfamily that plays a crucial role in the precise segregation of chromosomes during mitosis. The abnormal function of TRIP13 has diverse functions, including mitotic processes, DNA repair pathways, and spindle assembly checkpoints, which may con...
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MDPI AG
2025-01-01
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| author | Surya P. Singh Krishnendu Goswami Gopal Pathuri Chinthalapally V. Rao Venkateshwar Madka |
| author_facet | Surya P. Singh Krishnendu Goswami Gopal Pathuri Chinthalapally V. Rao Venkateshwar Madka |
| author_sort | Surya P. Singh |
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| description | TRIP13 is a member of the large AAA+ ATPase protein superfamily that plays a crucial role in the precise segregation of chromosomes during mitosis. The abnormal function of TRIP13 has diverse functions, including mitotic processes, DNA repair pathways, and spindle assembly checkpoints, which may contribute to chromosomal instability (CIN). Emerging evidence suggests that the overexpression of TRIP13, observed in many cancers, plays a significant role in drug resistance, autophagy, and immune invasion. Recently, significant advances have been made in identifying TRIP13-associated signaling pathways that have been implicated in cancer progression. Several small molecules that specifically inhibit TRIP13 function and reduce cancer cell growth have been developed. Combination treatments, including TRIP13 inhibitors and other anticancer drugs, have shown promising results. While these findings are promising, TRIP13 inhibitors are awaiting clinical trials. This review discusses recent progress in understanding the oncogenic function of TRIP13 and its possible therapeutic targets, which could be exploited as an attractive option for cancer management. |
| format | Article |
| id | doaj-art-95dad2abf6644a7f81078bea339f420e |
| institution | OA Journals |
| issn | 2673-8856 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | DNA |
| spelling | doaj-art-95dad2abf6644a7f81078bea339f420e2025-08-20T02:11:01ZengMDPI AGDNA2673-88562025-01-0151310.3390/dna5010003Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising ApproachSurya P. Singh0Krishnendu Goswami1Gopal Pathuri2Chinthalapally V. Rao3Venkateshwar Madka4Center for Cancer Prevention and Drug Development, Stephenson Cancer Center, Hem-Onc Section, Department of Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USACenter for Cancer Prevention and Drug Development, Stephenson Cancer Center, Hem-Onc Section, Department of Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USACenter for Cancer Prevention and Drug Development, Stephenson Cancer Center, Hem-Onc Section, Department of Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USACenter for Cancer Prevention and Drug Development, Stephenson Cancer Center, Hem-Onc Section, Department of Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USACenter for Cancer Prevention and Drug Development, Stephenson Cancer Center, Hem-Onc Section, Department of Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USATRIP13 is a member of the large AAA+ ATPase protein superfamily that plays a crucial role in the precise segregation of chromosomes during mitosis. The abnormal function of TRIP13 has diverse functions, including mitotic processes, DNA repair pathways, and spindle assembly checkpoints, which may contribute to chromosomal instability (CIN). Emerging evidence suggests that the overexpression of TRIP13, observed in many cancers, plays a significant role in drug resistance, autophagy, and immune invasion. Recently, significant advances have been made in identifying TRIP13-associated signaling pathways that have been implicated in cancer progression. Several small molecules that specifically inhibit TRIP13 function and reduce cancer cell growth have been developed. Combination treatments, including TRIP13 inhibitors and other anticancer drugs, have shown promising results. While these findings are promising, TRIP13 inhibitors are awaiting clinical trials. This review discusses recent progress in understanding the oncogenic function of TRIP13 and its possible therapeutic targets, which could be exploited as an attractive option for cancer management.https://www.mdpi.com/2673-8856/5/1/3TRIP13cancerDNA repairmitosischromosomal instabilitydrug resistance |
| spellingShingle | Surya P. Singh Krishnendu Goswami Gopal Pathuri Chinthalapally V. Rao Venkateshwar Madka Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising Approach DNA TRIP13 cancer DNA repair mitosis chromosomal instability drug resistance |
| title | Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising Approach |
| title_full | Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising Approach |
| title_fullStr | Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising Approach |
| title_full_unstemmed | Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising Approach |
| title_short | Targeting Thyroid Hormone Receptor Interacting Protein (TRIP13) for Cancer Therapy: A Promising Approach |
| title_sort | targeting thyroid hormone receptor interacting protein trip13 for cancer therapy a promising approach |
| topic | TRIP13 cancer DNA repair mitosis chromosomal instability drug resistance |
| url | https://www.mdpi.com/2673-8856/5/1/3 |
| work_keys_str_mv | AT suryapsingh targetingthyroidhormonereceptorinteractingproteintrip13forcancertherapyapromisingapproach AT krishnendugoswami targetingthyroidhormonereceptorinteractingproteintrip13forcancertherapyapromisingapproach AT gopalpathuri targetingthyroidhormonereceptorinteractingproteintrip13forcancertherapyapromisingapproach AT chinthalapallyvrao targetingthyroidhormonereceptorinteractingproteintrip13forcancertherapyapromisingapproach AT venkateshwarmadka targetingthyroidhormonereceptorinteractingproteintrip13forcancertherapyapromisingapproach |