Analyzing the ophthalmic red reflex test in children with congenital Zika syndrome
ABSTRACT Objective: To evaluate the red reflex test in children with congenital Zika syndrome in order to predict the occurrence of retinal lesion or optic nerve hypoplasia in these patients. Methods: A descriptive cohort study was conducted in children with Congenital Zika Syndrome. The red refle...
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Sociedade Brasileira de Oftalmologia
2025-06-01
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| Series: | Revista Brasileira de Oftalmologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100218&lng=en&tlng=en |
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| author | Marcia Beatriz Tartarella Islane Maria Castro Verçosa Paloma Castro Verçosa Paula Carneiro Reno Castro Verçosa Eduarda Tartarella-Nascimento Luciano Pamplona de Goés Cavalcanti Erlane Marques Ribeiro João Borges Fortes Filho |
| author_facet | Marcia Beatriz Tartarella Islane Maria Castro Verçosa Paloma Castro Verçosa Paula Carneiro Reno Castro Verçosa Eduarda Tartarella-Nascimento Luciano Pamplona de Goés Cavalcanti Erlane Marques Ribeiro João Borges Fortes Filho |
| author_sort | Marcia Beatriz Tartarella |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate the red reflex test in children with congenital Zika syndrome in order to predict the occurrence of retinal lesion or optic nerve hypoplasia in these patients. Methods: A descriptive cohort study was conducted in children with Congenital Zika Syndrome. The red reflex test was performed with a direct ophthalmoscope, and it was repeated after pupils’ dilation. The patients underwent a comprehensive ophthalmological evaluation. Eye fundus was analyzed by binocular indirect ophthalmoscopy. The occurrence of macular atrophy or optic nerve hypoplasia was recorded. Results: A total of 144 eyes from 72 infants were included. All children had microcephaly. The mean age ranged from 1 to 18 months of life (median = 10 months), and 54.2% were female. Congenital Zika syndrome ocular features (macular atrophy or optic nerve hypoplasia) were detected in a total of 50 eyes. In all of the 144 eyes, the red reflex was present, thus the red reflex test was considered normal without or with pupillary dilation, despite differences in the color nuances observed. Conclusion: Red reflex test did not enhance the assessment of the occurrence of macular atrophic lesion or optic nerve hypoplasia in patients with congenital Zika syndrome. |
| format | Article |
| id | doaj-art-95d96f2c224d4861aecdcb4c0c18451f |
| institution | DOAJ |
| issn | 1982-8551 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sociedade Brasileira de Oftalmologia |
| record_format | Article |
| series | Revista Brasileira de Oftalmologia |
| spelling | doaj-art-95d96f2c224d4861aecdcb4c0c18451f2025-08-20T03:21:26ZengSociedade Brasileira de OftalmologiaRevista Brasileira de Oftalmologia1982-85512025-06-018410.37039/1982.8551.20250032Analyzing the ophthalmic red reflex test in children with congenital Zika syndromeMarcia Beatriz Tartarellahttps://orcid.org/0000-0003-2361-3355Islane Maria Castro Verçosahttps://orcid.org/0000-0002-6669-7934Paloma Castro Verçosahttps://orcid.org/0000-0002-3590-3459Paula Carneirohttps://orcid.org/0000-0001-7649-1983Reno Castro Verçosahttps://orcid.org/0009-0006-4231-4296Eduarda Tartarella-Nascimentohttps://orcid.org/0009-0007-5855-4902Luciano Pamplona de Goés Cavalcantihttps://orcid.org/0000-0002-3440-1182Erlane Marques Ribeirohttps://orcid.org/0000-0002-7104-0128João Borges Fortes Filhohttps://orcid.org/0000-0001-5682-0962ABSTRACT Objective: To evaluate the red reflex test in children with congenital Zika syndrome in order to predict the occurrence of retinal lesion or optic nerve hypoplasia in these patients. Methods: A descriptive cohort study was conducted in children with Congenital Zika Syndrome. The red reflex test was performed with a direct ophthalmoscope, and it was repeated after pupils’ dilation. The patients underwent a comprehensive ophthalmological evaluation. Eye fundus was analyzed by binocular indirect ophthalmoscopy. The occurrence of macular atrophy or optic nerve hypoplasia was recorded. Results: A total of 144 eyes from 72 infants were included. All children had microcephaly. The mean age ranged from 1 to 18 months of life (median = 10 months), and 54.2% were female. Congenital Zika syndrome ocular features (macular atrophy or optic nerve hypoplasia) were detected in a total of 50 eyes. In all of the 144 eyes, the red reflex was present, thus the red reflex test was considered normal without or with pupillary dilation, despite differences in the color nuances observed. Conclusion: Red reflex test did not enhance the assessment of the occurrence of macular atrophic lesion or optic nerve hypoplasia in patients with congenital Zika syndrome.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100218&lng=en&tlng=enRed reflex testCongenital Zika SyndromeZika virus infectionOptic nerve hypoplasia, MicrocephalyChildMacular atrophy |
| spellingShingle | Marcia Beatriz Tartarella Islane Maria Castro Verçosa Paloma Castro Verçosa Paula Carneiro Reno Castro Verçosa Eduarda Tartarella-Nascimento Luciano Pamplona de Goés Cavalcanti Erlane Marques Ribeiro João Borges Fortes Filho Analyzing the ophthalmic red reflex test in children with congenital Zika syndrome Revista Brasileira de Oftalmologia Red reflex test Congenital Zika Syndrome Zika virus infection Optic nerve hypoplasia, Microcephaly Child Macular atrophy |
| title | Analyzing the ophthalmic red reflex test in children with congenital Zika syndrome |
| title_full | Analyzing the ophthalmic red reflex test in children with congenital Zika syndrome |
| title_fullStr | Analyzing the ophthalmic red reflex test in children with congenital Zika syndrome |
| title_full_unstemmed | Analyzing the ophthalmic red reflex test in children with congenital Zika syndrome |
| title_short | Analyzing the ophthalmic red reflex test in children with congenital Zika syndrome |
| title_sort | analyzing the ophthalmic red reflex test in children with congenital zika syndrome |
| topic | Red reflex test Congenital Zika Syndrome Zika virus infection Optic nerve hypoplasia, Microcephaly Child Macular atrophy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100218&lng=en&tlng=en |
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