Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonyls
Abstract Acrylamide, advanced glycation end products (AGEs), and alpha-dicarbonyls are formed during the thermal processing of foods. Their dietary intake raises potential health concerns. Using food frequency questionnaires on acrylamide-rich Slovak foods, we estimated dietary acrylamide intake in...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-98285-5 |
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| author | Katarína Šebeková Július Hodosy Peter Celec Lucie Marková Dávid Miláček Zuzana Ciesarová |
| author_facet | Katarína Šebeková Július Hodosy Peter Celec Lucie Marková Dávid Miláček Zuzana Ciesarová |
| author_sort | Katarína Šebeková |
| collection | DOAJ |
| description | Abstract Acrylamide, advanced glycation end products (AGEs), and alpha-dicarbonyls are formed during the thermal processing of foods. Their dietary intake raises potential health concerns. Using food frequency questionnaires on acrylamide-rich Slovak foods, we estimated dietary acrylamide intake in 107 students aged 19-to-30 years and correlated it with salivary, plasma, skin autofluorescence; plasma levels of soluble receptor for advanced glycated end-products, and oxidative status markers (thiobarbituric acid reacting substances, ferric-reducing ability of plasma). No significant relationship was revealed between estimated daily acrylamide intake and analyzed biomarkers. As the extent of exposure to alpha-dicarbonyls and AGEs when consuming acrylamide-rich food remains unknown, we aligned acrylamide intake with that of glyoxal, methylglyoxal, 3-deoxyglucosone, and Nε-carboxymethyllysine, Nε-carboxyethyllysine, or methylglyoxal-derived hydroimidazolone. Correlation coefficients between intakes of acrylamide and alpha-dicarbonyls or AGEs reached 0.7-to-0.8 (p < 0.001, all), but, at individual levels, high intake of acrylamide was not unequivocally associated with high intake of AGEs or alpha-dicarbonyls. Our data suggest that the restriction of dietary AGEs recommended to patients with chronic non-communicable diseases must not simultaneously mitigate acrylamide intake. Nutritional research should explore the potential cumulative or synergistic adverse health effects of concurrent dietary intakes of acrylamide, AGEs, and alpha-dicarbonyls. |
| format | Article |
| id | doaj-art-95d470d8817d4aaa9367f98e49e1eb47 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-95d470d8817d4aaa9367f98e49e1eb472025-08-20T03:52:19ZengNature PortfolioScientific Reports2045-23222025-04-0115111110.1038/s41598-025-98285-5Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonylsKatarína Šebeková0Július Hodosy1Peter Celec2Lucie Marková3Dávid Miláček4Zuzana Ciesarová5Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in BratislavaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University in BratislavaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University in BratislavaNational Agricultural and Food Centre, Food Research InstituteInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University in BratislavaNational Agricultural and Food Centre, Food Research InstituteAbstract Acrylamide, advanced glycation end products (AGEs), and alpha-dicarbonyls are formed during the thermal processing of foods. Their dietary intake raises potential health concerns. Using food frequency questionnaires on acrylamide-rich Slovak foods, we estimated dietary acrylamide intake in 107 students aged 19-to-30 years and correlated it with salivary, plasma, skin autofluorescence; plasma levels of soluble receptor for advanced glycated end-products, and oxidative status markers (thiobarbituric acid reacting substances, ferric-reducing ability of plasma). No significant relationship was revealed between estimated daily acrylamide intake and analyzed biomarkers. As the extent of exposure to alpha-dicarbonyls and AGEs when consuming acrylamide-rich food remains unknown, we aligned acrylamide intake with that of glyoxal, methylglyoxal, 3-deoxyglucosone, and Nε-carboxymethyllysine, Nε-carboxyethyllysine, or methylglyoxal-derived hydroimidazolone. Correlation coefficients between intakes of acrylamide and alpha-dicarbonyls or AGEs reached 0.7-to-0.8 (p < 0.001, all), but, at individual levels, high intake of acrylamide was not unequivocally associated with high intake of AGEs or alpha-dicarbonyls. Our data suggest that the restriction of dietary AGEs recommended to patients with chronic non-communicable diseases must not simultaneously mitigate acrylamide intake. Nutritional research should explore the potential cumulative or synergistic adverse health effects of concurrent dietary intakes of acrylamide, AGEs, and alpha-dicarbonyls.https://doi.org/10.1038/s41598-025-98285-5Dietary advanced glycation end-productsDietary alpha-dicarbonylsFood-frequency questionnairesRAGETBARSFRAP |
| spellingShingle | Katarína Šebeková Július Hodosy Peter Celec Lucie Marková Dávid Miláček Zuzana Ciesarová Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonyls Scientific Reports Dietary advanced glycation end-products Dietary alpha-dicarbonyls Food-frequency questionnaire sRAGE TBARS FRAP |
| title | Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonyls |
| title_full | Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonyls |
| title_fullStr | Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonyls |
| title_full_unstemmed | Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonyls |
| title_short | Association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end-products or alpha-dicarbonyls |
| title_sort | association of acrylamide dietary intake with glycation and oxidative status biomarkers and intakes of advanced glycation end products or alpha dicarbonyls |
| topic | Dietary advanced glycation end-products Dietary alpha-dicarbonyls Food-frequency questionnaire sRAGE TBARS FRAP |
| url | https://doi.org/10.1038/s41598-025-98285-5 |
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