Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice
Abstract Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related neurodegenerative diseases such as Alzheimer’s disease later in life. The present...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Journal of Physiological Sciences |
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| Online Access: | https://doi.org/10.1186/s12576-024-00907-6 |
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| author | Ayane Ninomiya Izuki Amano Hiraku Suzuki Yuki Fujiwara Asahi Haijima Noriyuki Koibuchi |
| author_facet | Ayane Ninomiya Izuki Amano Hiraku Suzuki Yuki Fujiwara Asahi Haijima Noriyuki Koibuchi |
| author_sort | Ayane Ninomiya |
| collection | DOAJ |
| description | Abstract Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related neurodegenerative diseases such as Alzheimer’s disease later in life. The present study investigated the effects of lactational PFOS exposure on cognitive function using one-year-old mice. Dams were exposed to PFOS (1 mg/kg body weight) through lactation by gavage. Male offspring were used for the behavior test battery to assess cognitive function. Western blot analysis was conducted to measure the levels of proteins related to the pathogenesis of Alzheimer’s disease. PFOS-exposed mice displayed a mild deficiency in social recognition. In the hippocampus, the expression of tau protein was significantly increased. These results underline a mild effect of developing PFOS exposure on cognitive function and neurodegeneration. The present study presents the long-lasting effects of PFOS in middle-aged period and warrants a potential aftermath. |
| format | Article |
| id | doaj-art-95cbef2c9c3842eba53e069cb7046cfd |
| institution | DOAJ |
| issn | 1880-6562 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj-art-95cbef2c9c3842eba53e069cb7046cfd2025-08-20T02:54:37ZengElsevierJournal of Physiological Sciences1880-65622024-03-0174111110.1186/s12576-024-00907-6Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male miceAyane Ninomiya0Izuki Amano1Hiraku Suzuki2Yuki Fujiwara3Asahi Haijima4Noriyuki Koibuchi5Department of Integrative Physiology, Gunma University Graduate School of MedicineDepartment of Integrative Physiology, Gunma University Graduate School of MedicineDepartment of Integrative Physiology, Gunma University Graduate School of MedicineDepartment of Integrative Physiology, Gunma University Graduate School of MedicineDepartment of Environmental Brain Science, Faculty of Human Sciences, Waseda UniversityDepartment of Integrative Physiology, Gunma University Graduate School of MedicineAbstract Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related neurodegenerative diseases such as Alzheimer’s disease later in life. The present study investigated the effects of lactational PFOS exposure on cognitive function using one-year-old mice. Dams were exposed to PFOS (1 mg/kg body weight) through lactation by gavage. Male offspring were used for the behavior test battery to assess cognitive function. Western blot analysis was conducted to measure the levels of proteins related to the pathogenesis of Alzheimer’s disease. PFOS-exposed mice displayed a mild deficiency in social recognition. In the hippocampus, the expression of tau protein was significantly increased. These results underline a mild effect of developing PFOS exposure on cognitive function and neurodegeneration. The present study presents the long-lasting effects of PFOS in middle-aged period and warrants a potential aftermath.https://doi.org/10.1186/s12576-024-00907-6Perfluorooctane sulfonate (PFOS)Alzheimer’s diseaseCognitive functionAging |
| spellingShingle | Ayane Ninomiya Izuki Amano Hiraku Suzuki Yuki Fujiwara Asahi Haijima Noriyuki Koibuchi Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice Journal of Physiological Sciences Perfluorooctane sulfonate (PFOS) Alzheimer’s disease Cognitive function Aging |
| title | Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice |
| title_full | Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice |
| title_fullStr | Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice |
| title_full_unstemmed | Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice |
| title_short | Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice |
| title_sort | lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle aged male mice |
| topic | Perfluorooctane sulfonate (PFOS) Alzheimer’s disease Cognitive function Aging |
| url | https://doi.org/10.1186/s12576-024-00907-6 |
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