Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review
ABSTRACT Scleromyxedema is an uncommon, chronic connective tissue disorder with an obscure etiology. It is distinguished by fibromyxoid skin lesions and elevated serum monoclonal immunoglobulin levels. The condition's rarity limits epidemiological data, making prevalence and incidence assessmen...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70741 |
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| author | Shanshan Liang Jingjing Zeng Peiying Zhong Chengyao Jia Li Zhang |
| author_facet | Shanshan Liang Jingjing Zeng Peiying Zhong Chengyao Jia Li Zhang |
| author_sort | Shanshan Liang |
| collection | DOAJ |
| description | ABSTRACT Scleromyxedema is an uncommon, chronic connective tissue disorder with an obscure etiology. It is distinguished by fibromyxoid skin lesions and elevated serum monoclonal immunoglobulin levels. The condition's rarity limits epidemiological data, making prevalence and incidence assessment difficult. Herein, we detail a clinical case of scleromyxedema, encompassing diagnosis and treatment, to augment medical understanding of this rare entity. The aim of this study is to delve into the complexities of diagnosing scleromyxedema, encompassing its diverse clinical presentations, with the goal of refining diagnostic acumen and expediting the identification process. This, in turn, mitigates the risks associated with diagnostic delays. Moreover, the imperative of instituting pertinent therapeutic measures is highlighted as a fundamental aspect of patient management, underscoring the significance of a tailored approach to treatment. Concurrently, this endeavor demands rigorous precision from clinical laboratory staff. The accurate provision of laboratory data is essential to prevent oversights and misinterpretations in diagnosing this rare condition. |
| format | Article |
| id | doaj-art-95cb9bc5d8ac4f15a1aeae041a07fa95 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-95cb9bc5d8ac4f15a1aeae041a07fa952025-08-22T07:33:07ZengWileyClinical Case Reports2050-09042025-08-01138n/an/a10.1002/ccr3.70741Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature ReviewShanshan Liang0Jingjing Zeng1Peiying Zhong2Chengyao Jia3Li Zhang4Department of Laboratory Medicine West China Hospital, Sichuan University Chengdu ChinaDepartment of Laboratory Medicine The First College of Clinical Medical Science, China Three Gorges University Yichang ChinaDepartment of Laboratory 363 Hospital Chengdu ChinaDepartment of Laboratory Medicine West China Hospital, Sichuan University Chengdu ChinaDepartment of Hematology West China Hospital, Sichuan University Chengdu ChinaABSTRACT Scleromyxedema is an uncommon, chronic connective tissue disorder with an obscure etiology. It is distinguished by fibromyxoid skin lesions and elevated serum monoclonal immunoglobulin levels. The condition's rarity limits epidemiological data, making prevalence and incidence assessment difficult. Herein, we detail a clinical case of scleromyxedema, encompassing diagnosis and treatment, to augment medical understanding of this rare entity. The aim of this study is to delve into the complexities of diagnosing scleromyxedema, encompassing its diverse clinical presentations, with the goal of refining diagnostic acumen and expediting the identification process. This, in turn, mitigates the risks associated with diagnostic delays. Moreover, the imperative of instituting pertinent therapeutic measures is highlighted as a fundamental aspect of patient management, underscoring the significance of a tailored approach to treatment. Concurrently, this endeavor demands rigorous precision from clinical laboratory staff. The accurate provision of laboratory data is essential to prevent oversights and misinterpretations in diagnosing this rare condition.https://doi.org/10.1002/ccr3.70741hypothyroidismintravenous immunoglobulinmonoclonal gammopathies of clinical significancemonoclonal immunoglobulinscleromyxedema |
| spellingShingle | Shanshan Liang Jingjing Zeng Peiying Zhong Chengyao Jia Li Zhang Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review Clinical Case Reports hypothyroidism intravenous immunoglobulin monoclonal gammopathies of clinical significance monoclonal immunoglobulin scleromyxedema |
| title | Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review |
| title_full | Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review |
| title_fullStr | Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review |
| title_full_unstemmed | Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review |
| title_short | Monoclonal Gammopathies of Clinical Significance—Scleromyxedema: A Case Report and Literature Review |
| title_sort | monoclonal gammopathies of clinical significance scleromyxedema a case report and literature review |
| topic | hypothyroidism intravenous immunoglobulin monoclonal gammopathies of clinical significance monoclonal immunoglobulin scleromyxedema |
| url | https://doi.org/10.1002/ccr3.70741 |
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