Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats
Intestinal fibrosis – a chronic and progressive process mediated by several factors – occurs in several fibrostenosing enteropathies, but most frequently in patients with Crohn’s disease (CD). Despite the advances made in the understanding of CD and its management over the past 20 years, surgical in...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2012/628268 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849693013128773632 |
|---|---|
| author | Dov Wengrower Giuliana Zanninelli Giovanni Latella Stefano Necozione Issa Metanes Eran Israeli Joseph Lysy Mark Pines Orit Papo Eran Goldin |
| author_facet | Dov Wengrower Giuliana Zanninelli Giovanni Latella Stefano Necozione Issa Metanes Eran Israeli Joseph Lysy Mark Pines Orit Papo Eran Goldin |
| author_sort | Dov Wengrower |
| collection | DOAJ |
| description | Intestinal fibrosis – a chronic and progressive process mediated by several factors – occurs in several fibrostenosing enteropathies, but most frequently in patients with Crohn’s disease (CD). Despite the advances made in the understanding of CD and its management over the past 20 years, surgical intervention remains the only treatment strategy for patients with fibrostenosing CD. The results of several studies, however, have suggested that fibrosis may be a reversible and/or preventable phenomenon. Following an overview summarizing the contemporary knowledge regarding the cellular, cytokine and growth factor interactions that contribute to inflammation and the progression of fibrosis, this article describes an experimental animal model of colitis resembling human CD, which the authors used to investigate whether losartan, an angiotensin II receptor antagonist, could be used as a prophylactic agent to reduce the risk of intestinal fibrosis and strictures in patients with CD. |
| format | Article |
| id | doaj-art-95c36824fb614ae79da433768095b4a2 |
| institution | DOAJ |
| issn | 0835-7900 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-95c36824fb614ae79da433768095b4a22025-08-20T03:20:33ZengWileyCanadian Journal of Gastroenterology0835-79002012-01-01261333910.1155/2012/628268Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in RatsDov Wengrower0Giuliana Zanninelli1Giovanni Latella2Stefano Necozione3Issa Metanes4Eran Israeli5Joseph Lysy6Mark Pines7Orit Papo8Eran Goldin9Institute of Gastroenterology, Hadassah University Hospital, Jerusalem, IsraelGastroenterology Unit, University of L’Aquila, L’Aquila, ItalyGastroenterology Unit, University of L’Aquila, L’Aquila, ItalyClinical Epidemiology Unit, Department of Internal Medicine and Public Health, University of L’Aquila, L’Aquila, ItalyInstitute of Gastroenterology, Hadassah University Hospital, Jerusalem, IsraelInstitute of Gastroenterology, Hadassah University Hospital, Jerusalem, IsraelInstitute of Gastroenterology, Hadassah University Hospital, Jerusalem, IsraelInstitute of Animal Science, The Volcani Center, Bet Dagan, IsraelDepartment of Pathology, Hadassah University Hospital, Jerusalem, IsraelInstitute of Gastroenterology, Hadassah University Hospital, Jerusalem, IsraelIntestinal fibrosis – a chronic and progressive process mediated by several factors – occurs in several fibrostenosing enteropathies, but most frequently in patients with Crohn’s disease (CD). Despite the advances made in the understanding of CD and its management over the past 20 years, surgical intervention remains the only treatment strategy for patients with fibrostenosing CD. The results of several studies, however, have suggested that fibrosis may be a reversible and/or preventable phenomenon. Following an overview summarizing the contemporary knowledge regarding the cellular, cytokine and growth factor interactions that contribute to inflammation and the progression of fibrosis, this article describes an experimental animal model of colitis resembling human CD, which the authors used to investigate whether losartan, an angiotensin II receptor antagonist, could be used as a prophylactic agent to reduce the risk of intestinal fibrosis and strictures in patients with CD.http://dx.doi.org/10.1155/2012/628268 |
| spellingShingle | Dov Wengrower Giuliana Zanninelli Giovanni Latella Stefano Necozione Issa Metanes Eran Israeli Joseph Lysy Mark Pines Orit Papo Eran Goldin Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats Canadian Journal of Gastroenterology |
| title | Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats |
| title_full | Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats |
| title_fullStr | Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats |
| title_full_unstemmed | Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats |
| title_short | Losartan Reduces Trinitrobenzene Sulphonic Acid-Induced Colorectal Fibrosis in Rats |
| title_sort | losartan reduces trinitrobenzene sulphonic acid induced colorectal fibrosis in rats |
| url | http://dx.doi.org/10.1155/2012/628268 |
| work_keys_str_mv | AT dovwengrower losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT giulianazanninelli losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT giovannilatella losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT stefanonecozione losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT issametanes losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT eranisraeli losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT josephlysy losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT markpines losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT oritpapo losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats AT erangoldin losartanreducestrinitrobenzenesulphonicacidinducedcolorectalfibrosisinrats |