Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy
The global prevalence of diabetes is estimated to be 336 million people, with diabetic complications contributing to significant worldwide morbidity and mortality. Diabetic retinopathy results from cumulative microvascular damage to the retina and inflammation is recognized as a critical driver of t...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/629452 |
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| _version_ | 1850209121421230080 |
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| author | Daniel Gologorsky Aristomenis Thanos Demetrios Vavvas |
| author_facet | Daniel Gologorsky Aristomenis Thanos Demetrios Vavvas |
| author_sort | Daniel Gologorsky |
| collection | DOAJ |
| description | The global prevalence of diabetes is estimated to be 336 million people, with diabetic complications contributing to significant worldwide morbidity and mortality. Diabetic retinopathy results from cumulative microvascular damage to the retina and inflammation is recognized as a critical driver of this disease process. This paper outlines the pathophysiology leading to proliferative diabetic retinopathy and highlights many of the inflammatory, angiogenic, and cytokine mediators implicated in the development and progression of this disease. We focus a detailed discussion on the current targeted therapeutic interventions used to treat diabetic retinopathy. |
| format | Article |
| id | doaj-art-95c04b940d30467294ac8bd4b7b2cb2d |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-95c04b940d30467294ac8bd4b7b2cb2d2025-08-20T02:10:06ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/629452629452Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic RetinopathyDaniel Gologorsky0Aristomenis Thanos1Demetrios Vavvas2Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02131, USARetina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02131, USARetina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02131, USAThe global prevalence of diabetes is estimated to be 336 million people, with diabetic complications contributing to significant worldwide morbidity and mortality. Diabetic retinopathy results from cumulative microvascular damage to the retina and inflammation is recognized as a critical driver of this disease process. This paper outlines the pathophysiology leading to proliferative diabetic retinopathy and highlights many of the inflammatory, angiogenic, and cytokine mediators implicated in the development and progression of this disease. We focus a detailed discussion on the current targeted therapeutic interventions used to treat diabetic retinopathy.http://dx.doi.org/10.1155/2012/629452 |
| spellingShingle | Daniel Gologorsky Aristomenis Thanos Demetrios Vavvas Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy Mediators of Inflammation |
| title | Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy |
| title_full | Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy |
| title_fullStr | Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy |
| title_full_unstemmed | Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy |
| title_short | Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy |
| title_sort | therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2012/629452 |
| work_keys_str_mv | AT danielgologorsky therapeuticinterventionsagainstinflammatoryandangiogenicmediatorsinproliferativediabeticretinopathy AT aristomenisthanos therapeuticinterventionsagainstinflammatoryandangiogenicmediatorsinproliferativediabeticretinopathy AT demetriosvavvas therapeuticinterventionsagainstinflammatoryandangiogenicmediatorsinproliferativediabeticretinopathy |