A Success Story Leading Us to Think Big!
Immune dysregulation is the hallmark of all autoimmune diseases. It is extremely interesting to study the associations and pathogenesis of the various autoimmune diseases, like the link between the AIHA and CLL. This link is well established and is based on the fact that there is loss of tolerance t...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2011/215675 |
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| _version_ | 1850209205465645056 |
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| author | Jasmine Kamboj Rahul Kamboj Tejas Shah Pam Khosla |
| author_facet | Jasmine Kamboj Rahul Kamboj Tejas Shah Pam Khosla |
| author_sort | Jasmine Kamboj |
| collection | DOAJ |
| description | Immune dysregulation is the hallmark of all autoimmune
diseases. It is extremely interesting to study the associations
and pathogenesis of the various autoimmune diseases, like
the link between the AIHA and CLL. This link is well
established and is based on the fact that there is loss of
tolerance to the self-antigen, which in turn leads to immunebased
hemolytic anemia. Around 30% of the patients
with CLL are at the risk of developing AIHA, and 11%
eventually develop AIHA. Whether there is any definite
linkup between the corrupted immune system and “acute”
leukemias/lymphomas is yet to be established. Needless to
say, if there was an association between the pathogenesis of
the ALLs and AIHA, it would be a landmark in the field of
oncology as it would enforce early diagnosis and treatment
for the disease which is much more aggressive and found
in a comparatively younger age group (predominantly in
children and a mean age of 40 years in adults) as compared
to its chronic counterparts.
The AIHA would serve as a “tip to the underlying
iceberg” in these situations, warning us of the cryptic
diagnosis. |
| format | Article |
| id | doaj-art-95be9e75c50e482da6f3ea7c50173a0a |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-95be9e75c50e482da6f3ea7c50173a0a2025-08-20T02:10:05ZengWileyCase Reports in Hematology2090-65602090-65792011-01-01201110.1155/2011/215675215675A Success Story Leading Us to Think Big!Jasmine Kamboj0Rahul Kamboj1Tejas Shah2Pam Khosla3Department of Hematology and Oncology, Mout Sinai Medical Center, Chicago, IL, USADepartment of Hematology and Oncology, Mout Sinai Medical Center, Chicago, IL, USADepartment of Hematology and Oncology, Mout Sinai Medical Center, Chicago, IL, USADepartment of Hematology and Oncology, Mout Sinai Medical Center, Chicago, IL, USAImmune dysregulation is the hallmark of all autoimmune diseases. It is extremely interesting to study the associations and pathogenesis of the various autoimmune diseases, like the link between the AIHA and CLL. This link is well established and is based on the fact that there is loss of tolerance to the self-antigen, which in turn leads to immunebased hemolytic anemia. Around 30% of the patients with CLL are at the risk of developing AIHA, and 11% eventually develop AIHA. Whether there is any definite linkup between the corrupted immune system and “acute” leukemias/lymphomas is yet to be established. Needless to say, if there was an association between the pathogenesis of the ALLs and AIHA, it would be a landmark in the field of oncology as it would enforce early diagnosis and treatment for the disease which is much more aggressive and found in a comparatively younger age group (predominantly in children and a mean age of 40 years in adults) as compared to its chronic counterparts. The AIHA would serve as a “tip to the underlying iceberg” in these situations, warning us of the cryptic diagnosis.http://dx.doi.org/10.1155/2011/215675 |
| spellingShingle | Jasmine Kamboj Rahul Kamboj Tejas Shah Pam Khosla A Success Story Leading Us to Think Big! Case Reports in Hematology |
| title | A Success Story Leading Us to Think Big! |
| title_full | A Success Story Leading Us to Think Big! |
| title_fullStr | A Success Story Leading Us to Think Big! |
| title_full_unstemmed | A Success Story Leading Us to Think Big! |
| title_short | A Success Story Leading Us to Think Big! |
| title_sort | success story leading us to think big |
| url | http://dx.doi.org/10.1155/2011/215675 |
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