A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients
Introduction: Galectin-3 is a β-galactoside-binding lectin with several roles in the immune- inflammatory response. The aim of this systematic review and meta-analysis was to explain the prognostic value of Galectin-3 on COVID-19 severity and mortality from the existing literature. Methods: PubMed/...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Edizioni FS
2023-12-01
|
| Series: | Journal of Health and Social Sciences |
| Subjects: | |
| Online Access: | https://journalhss.com/wp-content/uploads/JHSS_SYST3.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595555078897664 |
|---|---|
| author | Kacper DZIEDZIC Kavita BATRA Michal PRUC Monika TOMASZEWSKA Krzysztof KUREK Murat YILDIRIM Mahmood BAHRAMIZADEH Francesco CHIRICO Nicola Luigi BRAGAZZI Hicham KHABBACHE Aldo SITIBONDO Lukasz SZARPAK Gabriella NUCERA |
| author_facet | Kacper DZIEDZIC Kavita BATRA Michal PRUC Monika TOMASZEWSKA Krzysztof KUREK Murat YILDIRIM Mahmood BAHRAMIZADEH Francesco CHIRICO Nicola Luigi BRAGAZZI Hicham KHABBACHE Aldo SITIBONDO Lukasz SZARPAK Gabriella NUCERA |
| author_sort | Kacper DZIEDZIC |
| collection | DOAJ |
| description | Introduction: Galectin-3 is a β-galactoside-binding lectin with several roles in the immune-
inflammatory response. The aim of this systematic review and meta-analysis was to explain the prognostic value of Galectin-3 on COVID-19 severity and mortality from the existing literature. Methods: PubMed/MEDLINE, EMBASE, SCOPUS, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were surveyed up to November 10, 2023, for studies reporting data on Galectin-3 levels and the severity and mortality of patients with COVID-19. We performed frequentist random-effects network meta-analysis and presented the standard mean difference (SMD) and 95% confidence interval (CI).
Results: Galectin-3 levels among patients with and without COVID-19 varied with the following values: 15.73±13.03 vs. 8.72±5.82 pg/mL, respectively (SMD = 2.59; 95%CI: 1.52 to 3.67; p<0.001). Galectin-3 levels were also statistically different between COVID-19 patients who were severe and those who were not (18.83±15.5 pg/mL vs. 12.43±10.29 pg/mL; SMD = 2.64; 95%CI: 1.45 to 3.83; p<0.001), as well as between COVID-19 patients who survived and those who died (6.24±6.74 pg/mL vs. 13.72±15.92 pg/mL; SMD = -1.79; 95%CI: -2.78 to -0.80; p<0.001).
Discussion: Galectin-3 seems to be a useful predictive biomarker of COVID-19 outcomes and needs further evaluation. |
| format | Article |
| id | doaj-art-95b60d06b56e4a6f83ceedae0403d339 |
| institution | Kabale University |
| issn | 2499-2240 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Edizioni FS |
| record_format | Article |
| series | Journal of Health and Social Sciences |
| spelling | doaj-art-95b60d06b56e4a6f83ceedae0403d3392025-01-18T18:20:30ZengEdizioni FSJournal of Health and Social Sciences2499-22402023-12-018428229410.19204/2023/SYST3A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patientsKacper DZIEDZICKavita BATRAMichal PRUCMonika TOMASZEWSKAKrzysztof KUREKMurat YILDIRIMMahmood BAHRAMIZADEHFrancesco CHIRICONicola Luigi BRAGAZZIHicham KHABBACHEAldo SITIBONDOLukasz SZARPAKGabriella NUCERAIntroduction: Galectin-3 is a β-galactoside-binding lectin with several roles in the immune- inflammatory response. The aim of this systematic review and meta-analysis was to explain the prognostic value of Galectin-3 on COVID-19 severity and mortality from the existing literature. Methods: PubMed/MEDLINE, EMBASE, SCOPUS, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were surveyed up to November 10, 2023, for studies reporting data on Galectin-3 levels and the severity and mortality of patients with COVID-19. We performed frequentist random-effects network meta-analysis and presented the standard mean difference (SMD) and 95% confidence interval (CI). Results: Galectin-3 levels among patients with and without COVID-19 varied with the following values: 15.73±13.03 vs. 8.72±5.82 pg/mL, respectively (SMD = 2.59; 95%CI: 1.52 to 3.67; p<0.001). Galectin-3 levels were also statistically different between COVID-19 patients who were severe and those who were not (18.83±15.5 pg/mL vs. 12.43±10.29 pg/mL; SMD = 2.64; 95%CI: 1.45 to 3.83; p<0.001), as well as between COVID-19 patients who survived and those who died (6.24±6.74 pg/mL vs. 13.72±15.92 pg/mL; SMD = -1.79; 95%CI: -2.78 to -0.80; p<0.001). Discussion: Galectin-3 seems to be a useful predictive biomarker of COVID-19 outcomes and needs further evaluation.https://journalhss.com/wp-content/uploads/JHSS_SYST3.pdfbiomarkercovid-19coronavirus disease 2019endothelial cellsgalectin-3gal-3mortalitysars-cov-2severe acute respiratory syndrome coronavirus 2 |
| spellingShingle | Kacper DZIEDZIC Kavita BATRA Michal PRUC Monika TOMASZEWSKA Krzysztof KUREK Murat YILDIRIM Mahmood BAHRAMIZADEH Francesco CHIRICO Nicola Luigi BRAGAZZI Hicham KHABBACHE Aldo SITIBONDO Lukasz SZARPAK Gabriella NUCERA A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients Journal of Health and Social Sciences biomarker covid-19 coronavirus disease 2019 endothelial cells galectin-3 gal-3 mortality sars-cov-2 severe acute respiratory syndrome coronavirus 2 |
| title | A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients |
| title_full | A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients |
| title_fullStr | A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients |
| title_full_unstemmed | A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients |
| title_short | A systematic review and meta-analysis of the association between galectin-3 levels and clinical outcomes in COVID-19 patients |
| title_sort | systematic review and meta analysis of the association between galectin 3 levels and clinical outcomes in covid 19 patients |
| topic | biomarker covid-19 coronavirus disease 2019 endothelial cells galectin-3 gal-3 mortality sars-cov-2 severe acute respiratory syndrome coronavirus 2 |
| url | https://journalhss.com/wp-content/uploads/JHSS_SYST3.pdf |
| work_keys_str_mv | AT kacperdziedzic asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT kavitabatra asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT michalpruc asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT monikatomaszewska asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT krzysztofkurek asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT muratyildirim asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT mahmoodbahramizadeh asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT francescochirico asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT nicolaluigibragazzi asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT hichamkhabbache asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT aldositibondo asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT lukaszszarpak asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT gabriellanucera asystematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT kacperdziedzic systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT kavitabatra systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT michalpruc systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT monikatomaszewska systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT krzysztofkurek systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT muratyildirim systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT mahmoodbahramizadeh systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT francescochirico systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT nicolaluigibragazzi systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT hichamkhabbache systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT aldositibondo systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT lukaszszarpak systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients AT gabriellanucera systematicreviewandmetaanalysisoftheassociationbetweengalectin3levelsandclinicaloutcomesincovid19patients |