Spore-inspired inhalation drug delivery system for asthma therapy
The delivery efficiency of drugs in the lung is crucial for inhaled therapies targeting pulmonary diseases. However, current inhalation carriers face challenges overcoming pulmonary barriers, leading to insufficient delivery efficiency. To tackle this limitation, we have developed a “spore-inspired”...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-11-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2500338X |
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| author | Mengqi Tong Xi Kuang Qiaoying Jiang Gaoxiang Li Lulu Jin Yihao Ye Yi Pan Yang Zhu Xiaozhou Mou Zhengwei Mao Yueliang Zheng |
| author_facet | Mengqi Tong Xi Kuang Qiaoying Jiang Gaoxiang Li Lulu Jin Yihao Ye Yi Pan Yang Zhu Xiaozhou Mou Zhengwei Mao Yueliang Zheng |
| author_sort | Mengqi Tong |
| collection | DOAJ |
| description | The delivery efficiency of drugs in the lung is crucial for inhaled therapies targeting pulmonary diseases. However, current inhalation carriers face challenges overcoming pulmonary barriers, leading to insufficient delivery efficiency. To tackle this limitation, we have developed a “spore-inspired” strategy. Ganoderma lucidum spores (GLS) provide dual delivery advantages: their natural morphology promotes bronchial-alveolar deposition while evading macrophage endocytosis, enhancing pulmonary retention. Using these features, a biomimetic carrier called carbonized GLS (cGLS) is created through precise carbonization, which preserves the spores’ natural morphological benefits while reducing the immune response and increasing drug-loading capacity. Subsequently, we develop the spore-inspired inhalation drug delivery system BUD-cGLS by loading the asthma medication budesonide (BUD), which facilitates accurate regulation of the “deposition-escape-release” process. In the OVA-induced asthma model, BUD-cGLS significantly reduces airway resistance, suppresses mucin secretion, and decreases inflammatory cytokines. Overall, these findings highlight the potential of this spore-inspired carrier as a promising inhalation platform for delivering drugs to treat asthma and other pulmonary diseases. |
| format | Article |
| id | doaj-art-95b27a3a12ed4deb96df29e3ccc57ab7 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-95b27a3a12ed4deb96df29e3ccc57ab72025-08-20T03:40:33ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-11-015380181810.1016/j.bioactmat.2025.07.045Spore-inspired inhalation drug delivery system for asthma therapyMengqi Tong0Xi Kuang1Qiaoying Jiang2Gaoxiang Li3Lulu Jin4Yihao Ye5Yi Pan6Yang Zhu7Xiaozhou Mou8Zhengwei Mao9Yueliang Zheng10Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, China; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, ChinaEmergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, ChinaSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053, ChinaEmergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, ChinaClinical Research Institute, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, ChinaEmergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, China; The Second School of Clinical Medicine, Hangzhou Normal University, Hangzhou, 311121, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, ChinaClinical Research Institute, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, China; Corresponding author.MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China; Corresponding author.Emergency and Critical Care Center, Department of Emergency Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, China; Corresponding author.The delivery efficiency of drugs in the lung is crucial for inhaled therapies targeting pulmonary diseases. However, current inhalation carriers face challenges overcoming pulmonary barriers, leading to insufficient delivery efficiency. To tackle this limitation, we have developed a “spore-inspired” strategy. Ganoderma lucidum spores (GLS) provide dual delivery advantages: their natural morphology promotes bronchial-alveolar deposition while evading macrophage endocytosis, enhancing pulmonary retention. Using these features, a biomimetic carrier called carbonized GLS (cGLS) is created through precise carbonization, which preserves the spores’ natural morphological benefits while reducing the immune response and increasing drug-loading capacity. Subsequently, we develop the spore-inspired inhalation drug delivery system BUD-cGLS by loading the asthma medication budesonide (BUD), which facilitates accurate regulation of the “deposition-escape-release” process. In the OVA-induced asthma model, BUD-cGLS significantly reduces airway resistance, suppresses mucin secretion, and decreases inflammatory cytokines. Overall, these findings highlight the potential of this spore-inspired carrier as a promising inhalation platform for delivering drugs to treat asthma and other pulmonary diseases.http://www.sciencedirect.com/science/article/pii/S2452199X2500338XPulmonary deliverySpore-inspired carrierBudesonideAsthmaDry powder inhaler |
| spellingShingle | Mengqi Tong Xi Kuang Qiaoying Jiang Gaoxiang Li Lulu Jin Yihao Ye Yi Pan Yang Zhu Xiaozhou Mou Zhengwei Mao Yueliang Zheng Spore-inspired inhalation drug delivery system for asthma therapy Bioactive Materials Pulmonary delivery Spore-inspired carrier Budesonide Asthma Dry powder inhaler |
| title | Spore-inspired inhalation drug delivery system for asthma therapy |
| title_full | Spore-inspired inhalation drug delivery system for asthma therapy |
| title_fullStr | Spore-inspired inhalation drug delivery system for asthma therapy |
| title_full_unstemmed | Spore-inspired inhalation drug delivery system for asthma therapy |
| title_short | Spore-inspired inhalation drug delivery system for asthma therapy |
| title_sort | spore inspired inhalation drug delivery system for asthma therapy |
| topic | Pulmonary delivery Spore-inspired carrier Budesonide Asthma Dry powder inhaler |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2500338X |
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