Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy
Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8175898 |
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| author | Sui-Ling Liao Shen-Hao Lai Ming-Han Tsai Man-Chin Hua Kuo-Wei Yeh Kuan-Wen Su Chi-Hsin Chiang Shih-Yin Huang Chuan-Chi Kao Tsung-Chieh Yao Jing-Long Huang |
| author_facet | Sui-Ling Liao Shen-Hao Lai Ming-Han Tsai Man-Chin Hua Kuo-Wei Yeh Kuan-Wen Su Chi-Hsin Chiang Shih-Yin Huang Chuan-Chi Kao Tsung-Chieh Yao Jing-Long Huang |
| author_sort | Sui-Ling Liao |
| collection | DOAJ |
| description | Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r=0.67, p<0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p=0.004) and TLR7-8 stimulation (p=0.006). However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration. There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy. In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response. |
| format | Article |
| id | doaj-art-95af18b112e340769717f1cb4abdd3d0 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-95af18b112e340769717f1cb4abdd3d02025-08-20T03:20:33ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/81758988175898Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in InfancySui-Ling Liao0Shen-Hao Lai1Ming-Han Tsai2Man-Chin Hua3Kuo-Wei Yeh4Kuan-Wen Su5Chi-Hsin Chiang6Shih-Yin Huang7Chuan-Chi Kao8Tsung-Chieh Yao9Jing-Long Huang10Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, TaiwanReports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r=0.67, p<0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p=0.004) and TLR7-8 stimulation (p=0.006). However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration. There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy. In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.http://dx.doi.org/10.1155/2016/8175898 |
| spellingShingle | Sui-Ling Liao Shen-Hao Lai Ming-Han Tsai Man-Chin Hua Kuo-Wei Yeh Kuan-Wen Su Chi-Hsin Chiang Shih-Yin Huang Chuan-Chi Kao Tsung-Chieh Yao Jing-Long Huang Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy Mediators of Inflammation |
| title | Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy |
| title_full | Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy |
| title_fullStr | Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy |
| title_full_unstemmed | Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy |
| title_short | Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy |
| title_sort | maternal vitamin d level is associated with viral toll like receptor triggered il 10 response but not the risk of infectious diseases in infancy |
| url | http://dx.doi.org/10.1155/2016/8175898 |
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