The influence of the sinonasal microbiome on the development and management of rhinosinusitis
Introduction and purpose: Chronic rhinosinusitis (CRS) is a frequently diagnosed condition in patients seeking medical care. It encompasses a range of disorders that can be classified based on underlying causes, clinical symptoms, or inflammatory types. Although the precise cause of CRS remains unc...
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56769 |
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| author | Miriam Lang Dawid Bereza Maria Kulak-Waśniewska Igor Moreau Paulina Polańska Katarzyna Sokołowska Barbara Woch |
| author_facet | Miriam Lang Dawid Bereza Maria Kulak-Waśniewska Igor Moreau Paulina Polańska Katarzyna Sokołowska Barbara Woch |
| author_sort | Miriam Lang |
| collection | DOAJ |
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Introduction and purpose: Chronic rhinosinusitis (CRS) is a frequently diagnosed condition in patients seeking medical care. It encompasses a range of disorders that can be classified based on underlying causes, clinical symptoms, or inflammatory types. Although the precise cause of CRS remains unclear, the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS 2020) has recently offered updated insights, treatment strategies, and recommendations.
State of knowledge: Recent research has increasingly focused on the role of the microbiota in inflammatory diseases. The optimal bacterial environment in the sinonasal mucosa, where inhaled bacteria, viruses, fungal spores, and particles initially interact, is still not fully understood. The dysbiosis theory, which emphasizes the importance of the microbiome and its relationship with the host, is the predominant model explaining CRS pathogenesis. Disruptions in this balance can lead to a variety of clinical manifestations in CRS patients.
Conclusions: Given the impact of CRS treatment on the composition of sinus and nasopharyngeal microbiota, the dysbiosis theory highlights the importance of addressing this aspect in therapeutic strategies. Ongoing research is exploring the potential use of pre- and probiotics as novel treatment options. A more thorough understanding of the microbiological factors involved in CRS is crucial for developing personalized, targeted therapies for affected individuals.
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| format | Article |
| id | doaj-art-95aadcc193334d5eb8c0c3fcb68c3495 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-95aadcc193334d5eb8c0c3fcb68c34952025-01-03T08:16:25ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56769The influence of the sinonasal microbiome on the development and management of rhinosinusitisMiriam Lang0https://orcid.org/0009-0002-5226-1467Dawid Bereza1https://orcid.org/0009-0007-7205-0671Maria Kulak-Waśniewska2https://orcid.org/0009-0000-6359-0560Igor Moreau3https://orcid.org/0000-0001-8872-0931Paulina Polańska4https://orcid.org/0009-0004-2365-7977Katarzyna Sokołowska5https://orcid.org/0009-0003-3145-243XBarbara Woch6https://orcid.org/0009-0003-2000-2687Lower Silesian Oncology CenterDr Alfred Sokolowski Specialist Hospital in Walbrzych, A. Sokołowskiego 4, 58-309 Walbrzych, PolandPomeranian Hospitals LLC, Polish Red Cross Maritime Hospital, ul. Powstania styczniowego 1, 81-519 Gdynia, PolandDivision of Pathophysiology, Department of Physiology and Pathophysiology, Wroclaw Medical University, Tytusa Chałubińskiego 10, 50-368 Wroclaw, PolandFaculty of Medicine, Wroclaw Medical University, Wybrzeże L. Pasteura 1, 50-367 Wroclaw, PolandDr Alfred Sokolowski Specialist Hospital in Walbrzych, A. Sokołowskiego 4, 58-309 Walbrzych, PolandPoviat Hospital Complex; Poviat Hospital in Oleśnica, Armii Krajowej 1, 56-400 Oleśnica Introduction and purpose: Chronic rhinosinusitis (CRS) is a frequently diagnosed condition in patients seeking medical care. It encompasses a range of disorders that can be classified based on underlying causes, clinical symptoms, or inflammatory types. Although the precise cause of CRS remains unclear, the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 (EPOS 2020) has recently offered updated insights, treatment strategies, and recommendations. State of knowledge: Recent research has increasingly focused on the role of the microbiota in inflammatory diseases. The optimal bacterial environment in the sinonasal mucosa, where inhaled bacteria, viruses, fungal spores, and particles initially interact, is still not fully understood. The dysbiosis theory, which emphasizes the importance of the microbiome and its relationship with the host, is the predominant model explaining CRS pathogenesis. Disruptions in this balance can lead to a variety of clinical manifestations in CRS patients. Conclusions: Given the impact of CRS treatment on the composition of sinus and nasopharyngeal microbiota, the dysbiosis theory highlights the importance of addressing this aspect in therapeutic strategies. Ongoing research is exploring the potential use of pre- and probiotics as novel treatment options. A more thorough understanding of the microbiological factors involved in CRS is crucial for developing personalized, targeted therapies for affected individuals. https://apcz.umk.pl/JEHS/article/view/56769microbiomenasal polypsrhinosinusitis |
| spellingShingle | Miriam Lang Dawid Bereza Maria Kulak-Waśniewska Igor Moreau Paulina Polańska Katarzyna Sokołowska Barbara Woch The influence of the sinonasal microbiome on the development and management of rhinosinusitis Journal of Education, Health and Sport microbiome nasal polyps rhinosinusitis |
| title | The influence of the sinonasal microbiome on the development and management of rhinosinusitis |
| title_full | The influence of the sinonasal microbiome on the development and management of rhinosinusitis |
| title_fullStr | The influence of the sinonasal microbiome on the development and management of rhinosinusitis |
| title_full_unstemmed | The influence of the sinonasal microbiome on the development and management of rhinosinusitis |
| title_short | The influence of the sinonasal microbiome on the development and management of rhinosinusitis |
| title_sort | influence of the sinonasal microbiome on the development and management of rhinosinusitis |
| topic | microbiome nasal polyps rhinosinusitis |
| url | https://apcz.umk.pl/JEHS/article/view/56769 |
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