Stimuli-responsive hydrogel dressing for wound healing
Wound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, and effective wound management is still a major challenge in clinical nursing settings. The wound microenvironment is collectively regulated by internal biomolecules, ex...
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2025-01-01
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| Series: | APL Materials |
| Online Access: | http://dx.doi.org/10.1063/5.0245545 |
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| author | Wei Zhang Jun Hu Hao Wu Xiufei Lin Limei Cai |
| author_facet | Wei Zhang Jun Hu Hao Wu Xiufei Lin Limei Cai |
| author_sort | Wei Zhang |
| collection | DOAJ |
| description | Wound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, and effective wound management is still a major challenge in clinical nursing settings. The wound microenvironment is collectively regulated by internal biomolecules, external drugs, and external sanitation. Traditional wound dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during wound healing and repair processes because they cannot respond to the dynamic wound microenvironment changes over the long-term. Stimulus-responsive biomaterials, which are activated by various factors intrinsic to the wound microenvironment or external influences, hold great promise for precise drug delivery and controlled release. Various stimulus-responsive hydrogels have been developed in recent years, exhibiting a range of “smart” properties, such as interacting with the wound, sensing wound conditions or environmental changes, and responding accordingly, thereby effectively promoting wound healing. This review discusses the latest advancements in stimulus-responsive hydrogels used in wound healing. We introduce the design scheme of stimulus-response hydrogels in detail based on the local wound biological/biochemical peculiarities (pH, reactive oxygen species glucose, and enzymes, etc.) and physical microenvironments (temperature, light, ultrasound, and electric fields, etc.). Furthermore, we explore several promising tissue-engineered constructs (nanofibers, scaffolds, microneedles, and microspheres). Finally, summarize stimulus-responsive wound dressings on the basis of active research challenges, current research progress, and development trends in the field. |
| format | Article |
| id | doaj-art-95a192a1a2b749fcbf50e41600bdbfc5 |
| institution | Kabale University |
| issn | 2166-532X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Materials |
| spelling | doaj-art-95a192a1a2b749fcbf50e41600bdbfc52025-02-03T16:42:31ZengAIP Publishing LLCAPL Materials2166-532X2025-01-01131010601010601-2410.1063/5.0245545Stimuli-responsive hydrogel dressing for wound healingWei Zhang0Jun Hu1Hao Wu2Xiufei Lin3Limei Cai4The Dingli Clinical College of Wenzhou Medical University (Wenzhou Central Hospital), Wenzhou 325000, ChinaThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, ChinaThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, ChinaThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, ChinaThe Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, ChinaWound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, and effective wound management is still a major challenge in clinical nursing settings. The wound microenvironment is collectively regulated by internal biomolecules, external drugs, and external sanitation. Traditional wound dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during wound healing and repair processes because they cannot respond to the dynamic wound microenvironment changes over the long-term. Stimulus-responsive biomaterials, which are activated by various factors intrinsic to the wound microenvironment or external influences, hold great promise for precise drug delivery and controlled release. Various stimulus-responsive hydrogels have been developed in recent years, exhibiting a range of “smart” properties, such as interacting with the wound, sensing wound conditions or environmental changes, and responding accordingly, thereby effectively promoting wound healing. This review discusses the latest advancements in stimulus-responsive hydrogels used in wound healing. We introduce the design scheme of stimulus-response hydrogels in detail based on the local wound biological/biochemical peculiarities (pH, reactive oxygen species glucose, and enzymes, etc.) and physical microenvironments (temperature, light, ultrasound, and electric fields, etc.). Furthermore, we explore several promising tissue-engineered constructs (nanofibers, scaffolds, microneedles, and microspheres). Finally, summarize stimulus-responsive wound dressings on the basis of active research challenges, current research progress, and development trends in the field.http://dx.doi.org/10.1063/5.0245545 |
| spellingShingle | Wei Zhang Jun Hu Hao Wu Xiufei Lin Limei Cai Stimuli-responsive hydrogel dressing for wound healing APL Materials |
| title | Stimuli-responsive hydrogel dressing for wound healing |
| title_full | Stimuli-responsive hydrogel dressing for wound healing |
| title_fullStr | Stimuli-responsive hydrogel dressing for wound healing |
| title_full_unstemmed | Stimuli-responsive hydrogel dressing for wound healing |
| title_short | Stimuli-responsive hydrogel dressing for wound healing |
| title_sort | stimuli responsive hydrogel dressing for wound healing |
| url | http://dx.doi.org/10.1063/5.0245545 |
| work_keys_str_mv | AT weizhang stimuliresponsivehydrogeldressingforwoundhealing AT junhu stimuliresponsivehydrogeldressingforwoundhealing AT haowu stimuliresponsivehydrogeldressingforwoundhealing AT xiufeilin stimuliresponsivehydrogeldressingforwoundhealing AT limeicai stimuliresponsivehydrogeldressingforwoundhealing |