Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs
Idiopathic epilepsy (IE) is the most common neurological disease in dogs. Approximately 1/3 of dogs with IE are resistant to anti-seizure medications (ASMs). Because the diagnosis of IE is largely based on the exclusion of other diseases, it would be beneficial to indicate an IE biomarker to better...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1480860/full |
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| author | Grace T. Kadler Alex zur Linden Luis Gaitero Fiona M. K. James |
| author_facet | Grace T. Kadler Alex zur Linden Luis Gaitero Fiona M. K. James |
| author_sort | Grace T. Kadler |
| collection | DOAJ |
| description | Idiopathic epilepsy (IE) is the most common neurological disease in dogs. Approximately 1/3 of dogs with IE are resistant to anti-seizure medications (ASMs). Because the diagnosis of IE is largely based on the exclusion of other diseases, it would be beneficial to indicate an IE biomarker to better understand, diagnose, and treat this disease. Diffusion tensor imaging (DTI), a magnetic resonance imaging (MRI) sequence, is used in human medicine to detect microstructural biomarkers of epilepsy. Based on the translational model between people and dogs, the use of DTI should be investigated in a veterinary context to determine if it is a viable resource for detecting microstructural white matter abnormalities in the brains of dogs with IE. As well, to determine if there are differences in white matter microstructure between dogs who are responsive to ASMs and dogs who are resistant to ASMs. Using DTI to better understand neurostructural abnormalities associated with IE and ASM resistance might help refine diagnostic approaches and treatment processes in veterinary medicine. |
| format | Article |
| id | doaj-art-959c2b2242f9494c9e4926db7f8863e1 |
| institution | OA Journals |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-959c2b2242f9494c9e4926db7f8863e12025-08-20T01:48:21ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.14808601480860Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogsGrace T. Kadler0Alex zur Linden1Luis Gaitero2Fiona M. K. James3Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, CanadaDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, CanadaDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, CanadaDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, CanadaIdiopathic epilepsy (IE) is the most common neurological disease in dogs. Approximately 1/3 of dogs with IE are resistant to anti-seizure medications (ASMs). Because the diagnosis of IE is largely based on the exclusion of other diseases, it would be beneficial to indicate an IE biomarker to better understand, diagnose, and treat this disease. Diffusion tensor imaging (DTI), a magnetic resonance imaging (MRI) sequence, is used in human medicine to detect microstructural biomarkers of epilepsy. Based on the translational model between people and dogs, the use of DTI should be investigated in a veterinary context to determine if it is a viable resource for detecting microstructural white matter abnormalities in the brains of dogs with IE. As well, to determine if there are differences in white matter microstructure between dogs who are responsive to ASMs and dogs who are resistant to ASMs. Using DTI to better understand neurostructural abnormalities associated with IE and ASM resistance might help refine diagnostic approaches and treatment processes in veterinary medicine.https://www.frontiersin.org/articles/10.3389/fvets.2024.1480860/fullidiopathic epilepsy (IE)dogsneuroimagingbiomarkermicrostructurediffusion tensor imaging (DTI) |
| spellingShingle | Grace T. Kadler Alex zur Linden Luis Gaitero Fiona M. K. James Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs Frontiers in Veterinary Science idiopathic epilepsy (IE) dogs neuroimaging biomarker microstructure diffusion tensor imaging (DTI) |
| title | Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs |
| title_full | Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs |
| title_fullStr | Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs |
| title_full_unstemmed | Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs |
| title_short | Diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs |
| title_sort | diffusion tensor imaging for detecting biomarkers of idiopathic epilepsy in dogs |
| topic | idiopathic epilepsy (IE) dogs neuroimaging biomarker microstructure diffusion tensor imaging (DTI) |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1480860/full |
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