Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases

Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases

Objective(s): This study aimed to investigate whether vericiguat exerts a protective effect against myocardial ischemia-reperfusion injury (MIRI) by inhibiting toll-like receptor 4 (TLR4) and c-Jun N-terminal kinases (JNK) activation and whether heat shock protein 90 (HSP90) mediates these effects.M...

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Bibliographic Details
Main Authors: Sijie Pan, Junyan Chen, Dongxiao Wang, Jianjun Meng, Min Wang, Guoqiang Zhong, Zhi-Yu Zeng, Ronghui Tu
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2025-09-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
hsp90
ischemic postconditioning
ischemic preconditioning
jnk
tlr4
vericiguat
Online Access:https://ijbms.mums.ac.ir/article_26075_afb7cd78170dee5a3717870b9df4ab3f.pdf
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