EV68-228-N monoclonal antibody treatment halts progression of paralysis in a mouse model of EV-D68 induced acute flaccid myelitis

EV68-228-N monoclonal antibody treatment halts progression of paralysis in a mouse model of EV-D68 induced acute flaccid myelitis

ABSTRACT In 2014, 2016, and 2018, infection with enterovirus D68 (EV-D68) was associated with outbreaks of a poliomyelitis-like paralytic syndrome, called acute flaccid myelitis (AFM). While only a small fraction of patients infected with EV-D68 developed AFM, this subgroup of patients does not typi...

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Bibliographic Details
Main Authors: Michael J. Rudy, Courtney J. Wilson, Brendan Hinckley, Danielle C. Baker, Joshua M. Royal, Marshall P. Hoke, Miles B. Brennan, Matthew R. Vogt, Penny Clarke, Kenneth L. Tyler
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
Enterovirus D-68
acute flaccid myelitis
treatment
monoclonal antibodies
Online Access:https://journals.asm.org/doi/10.1128/mbio.03906-24
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