Metronidazole-Induced Encephalopathy in a Patient Treated for Osteomyelitis
Metronidazole-induced encephalopathy (MIE) is a rare treatment complication associated with higher cumulative doses of metronidazole. Patients with underlying renal or hepatic dysfunction are at highest risk. Patients with MIE present with cerebellar dysfunction (for example, dysarthria, gait ataxia...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-06-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0857 |
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| Summary: | Metronidazole-induced encephalopathy (MIE) is a rare treatment complication associated with higher cumulative doses of metronidazole. Patients with underlying renal or hepatic dysfunction are at highest risk. Patients with MIE present with cerebellar dysfunction (for example, dysarthria, gait ataxia, and dysmetria) or encephalopathic symptoms, such as confusion. MIE is suspected when a patient presents with unexplained cerebellar dysfunction after prolonged metronidazole use, and it is confirmed on magnetic resonance imaging displaying lesions affecting the dentate nuclei or the corpus callosum. Herein, we present a case of MIE in a 73-year-old man with cirrhosis after receipt of a prolonged metronidazole course for bacterial spinal osteomyelitis. |
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| ISSN: | 2767-7664 |