miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition

miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition

Background: Neurogenic erectile dysfunction (ED) is a prevalent complication following radical prostatectomy in elderly patients, primarily resulting from the apoptosis of corpus cavernosum smooth muscle cells (CCSMCs) and the subsequent excessive fibrosis of the corpus cavernosum. Aim: This study a...

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Bibliographic Details
Main Authors: Yude Hong, Zejia Feng, Yunlong Ge, Yuhang Xi, Bowen Zhang, Jianjie Wu, Tian Xia, Bowen Tang, Wei Wang, Jun Chen, Hua Wang, Hengjun Xiao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Regenerative Therapy
Subjects:
Erectile dysfunction
Exosomes
miR-145
TGFBR2
Cavernous nerve injury
Online Access:http://www.sciencedirect.com/science/article/pii/S235232042500080X
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