The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast Cancer
Background: The most common cause of death linked to advanced stages of breast cancer (BC) is metastases. Newly, biomarkers of tumors are important due to their probable use in the early detection of the tumor. Many types of cancer were associated with hypoxia. The action of the hypoxia-inducible fa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_644_23 |
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| author | Sheerin H. Abbas Zinah Abbass Ali Alaa Sadiq Alaawad |
| author_facet | Sheerin H. Abbas Zinah Abbass Ali Alaa Sadiq Alaawad |
| author_sort | Sheerin H. Abbas |
| collection | DOAJ |
| description | Background: The most common cause of death linked to advanced stages of breast cancer (BC) is metastases. Newly, biomarkers of tumors are important due to their probable use in the early detection of the tumor. Many types of cancer were associated with hypoxia. The action of the hypoxia-inducible factors (HIFs), the component of the response to hypoxia and its adaptive, improves cancer complications like immune suppression, disturbed metabolism, angiogenesis, invasive, and metastasis. HIFs became important aim in anticancer therapy designation. Objectives: The aim of the present education is to evaluate HIF 1α (HIF-1A) and HIF 2α (HIF-2A) levels in the plasma of Babylon women with BC and control groups. Materials and Methods: The case–control group was made up of 50 women (presumably healthy women), whereas the sick group was made up of 50 women with BC. In plasma, the concentrations of HIF-1α (HIF-1A) and HIF-2α (HIF-2A) levels were evaluated by enzyme-linked immunosorbent assay (ELISA), and the statistical analysis was conducted by the SPSS software. Results: The results showed elevated HIF-1A and HIF-2A levels in the patient’s group compared with the control group (P < 0.05). Conclusion: The women with BC had elevated serum levels of HIF-1A and HIF-2A. Based on the results of this investigation, indicate the role of HIF-1A and HIF-2A as prognostic indicators in BC women. |
| format | Article |
| id | doaj-art-95873f1d3dea45929cc996d4787240ef |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-95873f1d3dea45929cc996d4787240ef2025-08-20T03:49:56ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602025-04-0122238438710.4103/MJBL.MJBL_644_23The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast CancerSheerin H. AbbasZinah Abbass AliAlaa Sadiq AlaawadBackground: The most common cause of death linked to advanced stages of breast cancer (BC) is metastases. Newly, biomarkers of tumors are important due to their probable use in the early detection of the tumor. Many types of cancer were associated with hypoxia. The action of the hypoxia-inducible factors (HIFs), the component of the response to hypoxia and its adaptive, improves cancer complications like immune suppression, disturbed metabolism, angiogenesis, invasive, and metastasis. HIFs became important aim in anticancer therapy designation. Objectives: The aim of the present education is to evaluate HIF 1α (HIF-1A) and HIF 2α (HIF-2A) levels in the plasma of Babylon women with BC and control groups. Materials and Methods: The case–control group was made up of 50 women (presumably healthy women), whereas the sick group was made up of 50 women with BC. In plasma, the concentrations of HIF-1α (HIF-1A) and HIF-2α (HIF-2A) levels were evaluated by enzyme-linked immunosorbent assay (ELISA), and the statistical analysis was conducted by the SPSS software. Results: The results showed elevated HIF-1A and HIF-2A levels in the patient’s group compared with the control group (P < 0.05). Conclusion: The women with BC had elevated serum levels of HIF-1A and HIF-2A. Based on the results of this investigation, indicate the role of HIF-1A and HIF-2A as prognostic indicators in BC women.https://doi.org/10.4103/MJBL.MJBL_644_23elisahypoxia-inducible factor 1α and 2αspss |
| spellingShingle | Sheerin H. Abbas Zinah Abbass Ali Alaa Sadiq Alaawad The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast Cancer Medical Journal of Babylon elisa hypoxia-inducible factor 1α and 2α spss |
| title | The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast Cancer |
| title_full | The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast Cancer |
| title_fullStr | The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast Cancer |
| title_full_unstemmed | The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast Cancer |
| title_short | The Effect of Hypoxia-Inducible Factors Levels in Sera of Babylon Women with Breast Cancer |
| title_sort | effect of hypoxia inducible factors levels in sera of babylon women with breast cancer |
| topic | elisa hypoxia-inducible factor 1α and 2α spss |
| url | https://doi.org/10.4103/MJBL.MJBL_644_23 |
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