High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical Applications
The power of the technique of high-performance liquid chromatography as an analytical tool is becoming widely recognized. In the field of peptide synthesis the method is being employed for both quality control and preparative isolation. Similarly, naturally occuring polypeptide hormones are being i...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
1981-09-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9531 |
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| _version_ | 1850170637344047104 |
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| author | Kenneth J. Wilson Graham J. Hughes |
| author_facet | Kenneth J. Wilson Graham J. Hughes |
| author_sort | Kenneth J. Wilson |
| collection | DOAJ |
| description |
The power of the technique of high-performance liquid chromatography as an analytical tool is becoming widely recognized. In the field of peptide synthesis the method is being employed for both quality control and preparative isolation. Similarly, naturally occuring polypeptide hormones are being isolated and characterized employing the method. Its use in identifying amino acid residues in proteins which were post translationally modified with pharmaceutical agents has been illustrated. Procedures, as employed in our laboratories, are given and applications illustrated for various problems which have arisen related to polypeptides, or chemical reactions thereon, which are of bio-medical/pharmaceutical relevance.
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| format | Article |
| id | doaj-art-9582f93e0c764b22b0fba8448f4bfecc |
| institution | OA Journals |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 1981-09-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-9582f93e0c764b22b0fba8448f4bfecc2025-08-20T02:20:26ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241981-09-0135910.2533/chimia.1981.327High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical ApplicationsKenneth J. Wilson0Graham J. Hughes1Biochemisches Institut der Universität Zürich, CH-8028 ZürichLaboratorium für Biochemie I der Eidgenössischen Technischen Hochschule, CH-8092 Zürich The power of the technique of high-performance liquid chromatography as an analytical tool is becoming widely recognized. In the field of peptide synthesis the method is being employed for both quality control and preparative isolation. Similarly, naturally occuring polypeptide hormones are being isolated and characterized employing the method. Its use in identifying amino acid residues in proteins which were post translationally modified with pharmaceutical agents has been illustrated. Procedures, as employed in our laboratories, are given and applications illustrated for various problems which have arisen related to polypeptides, or chemical reactions thereon, which are of bio-medical/pharmaceutical relevance. https://www.chimia.ch/chimia/article/view/9531 |
| spellingShingle | Kenneth J. Wilson Graham J. Hughes High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical Applications CHIMIA |
| title | High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical Applications |
| title_full | High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical Applications |
| title_fullStr | High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical Applications |
| title_full_unstemmed | High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical Applications |
| title_short | High-Performance Liquid Chromatography of Peptides and Proteins. Pharmaceutical and Bio-medical Applications |
| title_sort | high performance liquid chromatography of peptides and proteins pharmaceutical and bio medical applications |
| url | https://www.chimia.ch/chimia/article/view/9531 |
| work_keys_str_mv | AT kennethjwilson highperformanceliquidchromatographyofpeptidesandproteinspharmaceuticalandbiomedicalapplications AT grahamjhughes highperformanceliquidchromatographyofpeptidesandproteinspharmaceuticalandbiomedicalapplications |