Direct engulfment of synapses by overactivated microglia due to cadmium exposure and the protective role of Nrf2

Direct engulfment of synapses by overactivated microglia due to cadmium exposure and the protective role of Nrf2

Cadmium (Cd), a notorious environmental pollutant, has been linked to neurological disorders, but the underlying mechanism remains elusive. We aimed to explore the role of microglia in Cd-induced synaptic damages at environmentally relevant doses and whether microglia directly engulf synaptic struct...

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Bibliographic Details
Main Authors: Siyao Li, Mingdan You, Chengjie Chen, Jingqi Fu, Yuanyuan Xu, Jingbo Pi, Yi Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Cadmium
Microglia
Direct engulfment
Nrf2
Synapses
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324016968
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