Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure
Exposure to ionizing radiation destroys several biological processes by disturbing the membranes of cells and causing damage to DNA, proteins, and mitochondria. Increasing the use of ionizing radiation-based treatment and diagnosis techniques has been associated with the increased chronic diseases...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of science, university of Diyala
2025-04-01
|
| Series: | Academic Science Journal |
| Subjects: | |
| Online Access: | https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/558 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850151601398874112 |
|---|---|
| author | Lina Al-jameel Lujain Ghannawi Safaa Ehssan Haidar Fadhil Mohammed Amir |
| author_facet | Lina Al-jameel Lujain Ghannawi Safaa Ehssan Haidar Fadhil Mohammed Amir |
| author_sort | Lina Al-jameel |
| collection | DOAJ |
| description |
Exposure to ionizing radiation destroys several biological processes by disturbing the membranes of cells and causing damage to DNA, proteins, and mitochondria. Increasing the use of ionizing radiation-based treatment and diagnosis techniques has been associated with the increased chronic diseases among healthcare occupational and patients. However, numerous factors such as duration of exposure, radiation dose, dose rate, the organs of the body exposed, and the person's age impact the ionizing radiation-induced chronic effect. Exposure to ionizing radiation has various harmful effects on healthy tissues; long-term exposure to radiation increases the risk of carcinogenesis and autoimmune diseases such as diabetes. A recent study has also highlighted its potential role in the development of diabetes. This review examines the linkage between radiation-induced DNA damage and diabetes and Explores how radiation can contribute to the emergence and worsening of this chronic metabolic disorder. This review study aims to offer an exhaustive summary of how radiation-induced DNA damage promotes diabetes hazards, highlighting areas for future studies. Also, taking oral antioxidants to protect from radiation-induced DNA damage and mitigate oxidative damage and inflammatory markers after radiation exposure may reduce the incidence of diabetes. Radiation can cause damage to DNA through ionization, which creates free radicals that attack the DNA structure, leading to mutations or breaks in the DNA strands. If this damage occurs in cells involved in glucose regulation or insulin production, it may contribute to the development of diabetes.
|
| format | Article |
| id | doaj-art-957a707d6e3b46d5a150f4e59cb7d770 |
| institution | OA Journals |
| issn | 2958-4612 2959-5568 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | College of science, university of Diyala |
| record_format | Article |
| series | Academic Science Journal |
| spelling | doaj-art-957a707d6e3b46d5a150f4e59cb7d7702025-08-20T02:26:10ZengCollege of science, university of DiyalaAcademic Science Journal2958-46122959-55682025-04-013210.24237/ASJ.03.02.830BEffect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation ExposureLina Al-jameel0https://orcid.org/0009-0002-7073-5056Lujain Ghannawi1https://orcid.org/0009-0009-1067-6550Safaa Ehssan2https://orcid.org/0009-0004-8252-9967Haidar Fadhil3https://orcid.org/0000-0002-3912-8103Mohammed Amir4https://orcid.org/0009-0007-6823-1656NDC Mustansiriyah University Mustansiriyah UniversityNDC Mustansiriyah University Mustansiriyah UniversityNDC Mustansiriyah University Exposure to ionizing radiation destroys several biological processes by disturbing the membranes of cells and causing damage to DNA, proteins, and mitochondria. Increasing the use of ionizing radiation-based treatment and diagnosis techniques has been associated with the increased chronic diseases among healthcare occupational and patients. However, numerous factors such as duration of exposure, radiation dose, dose rate, the organs of the body exposed, and the person's age impact the ionizing radiation-induced chronic effect. Exposure to ionizing radiation has various harmful effects on healthy tissues; long-term exposure to radiation increases the risk of carcinogenesis and autoimmune diseases such as diabetes. A recent study has also highlighted its potential role in the development of diabetes. This review examines the linkage between radiation-induced DNA damage and diabetes and Explores how radiation can contribute to the emergence and worsening of this chronic metabolic disorder. This review study aims to offer an exhaustive summary of how radiation-induced DNA damage promotes diabetes hazards, highlighting areas for future studies. Also, taking oral antioxidants to protect from radiation-induced DNA damage and mitigate oxidative damage and inflammatory markers after radiation exposure may reduce the incidence of diabetes. Radiation can cause damage to DNA through ionization, which creates free radicals that attack the DNA structure, leading to mutations or breaks in the DNA strands. If this damage occurs in cells involved in glucose regulation or insulin production, it may contribute to the development of diabetes. https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/558Ionizing radiationDNA damageDiabetesFree radicalsMutations |
| spellingShingle | Lina Al-jameel Lujain Ghannawi Safaa Ehssan Haidar Fadhil Mohammed Amir Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure Academic Science Journal Ionizing radiation DNA damage Diabetes Free radicals Mutations |
| title | Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure |
| title_full | Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure |
| title_fullStr | Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure |
| title_full_unstemmed | Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure |
| title_short | Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure |
| title_sort | effect of dna damage on the development of diabetes mellitus due toionizing radiation exposure |
| topic | Ionizing radiation DNA damage Diabetes Free radicals Mutations |
| url | https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/558 |
| work_keys_str_mv | AT linaaljameel effectofdnadamageonthedevelopmentofdiabetesmellitusduetoionizingradiationexposure AT lujainghannawi effectofdnadamageonthedevelopmentofdiabetesmellitusduetoionizingradiationexposure AT safaaehssan effectofdnadamageonthedevelopmentofdiabetesmellitusduetoionizingradiationexposure AT haidarfadhil effectofdnadamageonthedevelopmentofdiabetesmellitusduetoionizingradiationexposure AT mohammedamir effectofdnadamageonthedevelopmentofdiabetesmellitusduetoionizingradiationexposure |