Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.

Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong in the host. In ∼4% of infected people, HTLV-1 causes a chronic disabling neuroinflammatory disease known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is unknown a...

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Bibliographic Details
Main Authors: Sonja Tattermusch, Jason A Skinner, Damien Chaussabel, Jacques Banchereau, Matthew P Berry, Finlay W McNab, Anne O'Garra, Graham P Taylor, Charles R M Bangham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002480&type=printable
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