Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention
Background. Coronary heart disease (CHD) is caused by the blockage or spasm of coronary arteries. Evidence shows that liver disease is related to CHD. However, the correlation between the Model for End-Stage Liver Disease (MELD) score and outcomes in patients after percutaneous coronary intervention...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6401092 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552793223725056 |
|---|---|
| author | You Chen Min Han Ying-Ying Zheng Feng Zhu Aikebai Aisan Tunike Maheshati Yi-Tong Ma Xiang Xie |
| author_facet | You Chen Min Han Ying-Ying Zheng Feng Zhu Aikebai Aisan Tunike Maheshati Yi-Tong Ma Xiang Xie |
| author_sort | You Chen |
| collection | DOAJ |
| description | Background. Coronary heart disease (CHD) is caused by the blockage or spasm of coronary arteries. Evidence shows that liver disease is related to CHD. However, the correlation between the Model for End-Stage Liver Disease (MELD) score and outcomes in patients after percutaneous coronary intervention (PCI) was unclear. Method. A retrospective cohort study involved 5373 patients with coronary heart disease after PCI was conducted from January 2008 to December 2016. Participants were classified to four groups according to the MELD score by quartiles. The primary endpoint was long-term mortality including all-case mortality (ACM) and cardiac mortality (CM). Secondary endpoints included bleeding events, readmission, major adverse cardiovascular events (MACE), major adverse cardiovascular, and cerebrovascular events (MACCE). The longest follow-up time was almost 10 years. Results. There were significant differences in the incidences of ACM (p=0.038) and CM (p=0.027) among the four MELD groups, but there was no significant difference in MACEs (p=0.496), MACCEs (p=0.234), readmission (p=0.684), and bleeding events (p=0.232). After adjusting the age, gender, smoking, drinking status, and diabetes by a multivariable Cox regression analysis, MELD remains independently associated with ACM (HR:1.57, 95%CI 1.052–2.354, p=0.027) and CM (HR:1.434, 95% CI 1.003–2.050, p=0.048). Conclusion. This study indicated that the MELD score had a strong prediction for long-term mortality in CHD patients who underwent PCI. |
| format | Article |
| id | doaj-art-956824092f3c431d9eae44a8a21761fd |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-956824092f3c431d9eae44a8a21761fd2025-02-03T05:57:52ZengWileyCardiology Research and Practice2090-80162090-05972021-01-01202110.1155/2021/64010926401092Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary InterventionYou Chen0Min Han1Ying-Ying Zheng2Feng Zhu3Aikebai Aisan4Tunike Maheshati5Yi-Tong Ma6Xiang Xie7Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaFuwai Central China Cardiovascular Hospital of Zhengzhou University, Department of Cardiology of Henan Provincial People's Hospital, Zhengzhou, ChinaDepartment of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaBackground. Coronary heart disease (CHD) is caused by the blockage or spasm of coronary arteries. Evidence shows that liver disease is related to CHD. However, the correlation between the Model for End-Stage Liver Disease (MELD) score and outcomes in patients after percutaneous coronary intervention (PCI) was unclear. Method. A retrospective cohort study involved 5373 patients with coronary heart disease after PCI was conducted from January 2008 to December 2016. Participants were classified to four groups according to the MELD score by quartiles. The primary endpoint was long-term mortality including all-case mortality (ACM) and cardiac mortality (CM). Secondary endpoints included bleeding events, readmission, major adverse cardiovascular events (MACE), major adverse cardiovascular, and cerebrovascular events (MACCE). The longest follow-up time was almost 10 years. Results. There were significant differences in the incidences of ACM (p=0.038) and CM (p=0.027) among the four MELD groups, but there was no significant difference in MACEs (p=0.496), MACCEs (p=0.234), readmission (p=0.684), and bleeding events (p=0.232). After adjusting the age, gender, smoking, drinking status, and diabetes by a multivariable Cox regression analysis, MELD remains independently associated with ACM (HR:1.57, 95%CI 1.052–2.354, p=0.027) and CM (HR:1.434, 95% CI 1.003–2.050, p=0.048). Conclusion. This study indicated that the MELD score had a strong prediction for long-term mortality in CHD patients who underwent PCI.http://dx.doi.org/10.1155/2021/6401092 |
| spellingShingle | You Chen Min Han Ying-Ying Zheng Feng Zhu Aikebai Aisan Tunike Maheshati Yi-Tong Ma Xiang Xie Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention Cardiology Research and Practice |
| title | Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention |
| title_full | Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention |
| title_fullStr | Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention |
| title_full_unstemmed | Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention |
| title_short | Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention |
| title_sort | model for end stage liver disease score predicts the mortality of patients with coronary heart disease who underwent percutaneous coronary intervention |
| url | http://dx.doi.org/10.1155/2021/6401092 |
| work_keys_str_mv | AT youchen modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention AT minhan modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention AT yingyingzheng modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention AT fengzhu modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention AT aikebaiaisan modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention AT tunikemaheshati modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention AT yitongma modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention AT xiangxie modelforendstageliverdiseasescorepredictsthemortalityofpatientswithcoronaryheartdiseasewhounderwentpercutaneouscoronaryintervention |