Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s disease
Introduction: Advanced Parkinson's disease severely affects gait. According to literature, deep brain stimulation of the subthalamic nucleus has scarce impact on gait in this disease. Objective: To evaluate and compare gait kinematics and parameters in patients with Advanced Parkinson's...
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| Format: | Article |
| Language: | English |
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FEADEF
2025-07-01
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| Series: | Retos: Nuevas Tendencias en Educación Física, Deportes y Recreación |
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| Online Access: | http://www.revistaretos.org/index.php/retos/article/view/110243 |
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| author | Juan F. Mier-García Lina M. Villegas-Trujillo Juan Camilo Salcedo Sebastián Ordoñez María José Uparela Fernanda Arbeláez Camilo A. Turriago-Pérez Lesbby Gómez-Salazar Óscar A. Escobar-Vidarte |
| author_facet | Juan F. Mier-García Lina M. Villegas-Trujillo Juan Camilo Salcedo Sebastián Ordoñez María José Uparela Fernanda Arbeláez Camilo A. Turriago-Pérez Lesbby Gómez-Salazar Óscar A. Escobar-Vidarte |
| author_sort | Juan F. Mier-García |
| collection | DOAJ |
| description |
Introduction: Advanced Parkinson's disease severely affects gait. According to literature, deep brain stimulation of the subthalamic nucleus has scarce impact on gait in this disease.
Objective: To evaluate and compare gait kinematics and parameters in patients with Advanced Parkinson's disease treated previously with deep brain stimulation of the subthalamic nucleus without anti-Parkinsonian medications, in ON and OFF modes of stimulation.
Methodology: This was a single-group pre-post quasi-experimental study and included 11 patients with idiopathic Advanced Parkinson's disease who were treated with deep brain stimulation of the subthalamic nucleus. Gait kinematic measurements were compared between the ON-OFF conditions within the same patients.
Results: A significantly greater range of joint movement was found in the ON condition vs. OFF condition in the knee (42.64° vs. 38.28°, p=0.04) and the ankle (20.42° vs. 16.58°, p=0.04). In the coronal plane, greater joint movement was found in the trunk (4.0° vs. 3.19°, p=0.05). Gait Deviation Index was significantly higher while in ON condition vs. OFF condition (80.23° vs. 75.15°, p=0.06).
Discussion: Although this study yields data that supports the fact that the deep brain stimulation of the subthalamic nucleus positively affects the gait characteristics studied and presented, there are others that have reported contradictory findings, possibly related to methodological limitations.
Conclusions: Patients presented an improvement in gait kinematics and parameters with the effects of deep brain stimulation of the subthalamic nucleus. Gait Deviation Index was sensitive to changes observed under ON-OFF conditions. Studies with larger number of patients are needed to draw more accurate conclusions.
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| format | Article |
| id | doaj-art-95579d1ce78a4af0b2a8492e35bf596b |
| institution | Kabale University |
| issn | 1579-1726 1988-2041 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | FEADEF |
| record_format | Article |
| series | Retos: Nuevas Tendencias en Educación Física, Deportes y Recreación |
| spelling | doaj-art-95579d1ce78a4af0b2a8492e35bf596b2025-08-20T03:32:57ZengFEADEFRetos: Nuevas Tendencias en Educación Física, Deportes y Recreación1579-17261988-20412025-07-017010.47197/retos.v70.110243Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s diseaseJuan F. Mier-García0Lina M. Villegas-Trujillo1Juan Camilo Salcedo2Sebastián Ordoñez3María José Uparela4Fernanda Arbeláez5Camilo A. Turriago-Pérez6Lesbby Gómez-Salazar7Óscar A. Escobar-VidarteUniversidad del ValleUniversidad del ValleUniversidad del ValleUniversidad del ValleUniversidad del ValleClínica ZereniaClínica ZereniaUniversidad del Valle Introduction: Advanced Parkinson's disease severely affects gait. According to literature, deep brain stimulation of the subthalamic nucleus has scarce impact on gait in this disease. Objective: To evaluate and compare gait kinematics and parameters in patients with Advanced Parkinson's disease treated previously with deep brain stimulation of the subthalamic nucleus without anti-Parkinsonian medications, in ON and OFF modes of stimulation. Methodology: This was a single-group pre-post quasi-experimental study and included 11 patients with idiopathic Advanced Parkinson's disease who were treated with deep brain stimulation of the subthalamic nucleus. Gait kinematic measurements were compared between the ON-OFF conditions within the same patients. Results: A significantly greater range of joint movement was found in the ON condition vs. OFF condition in the knee (42.64° vs. 38.28°, p=0.04) and the ankle (20.42° vs. 16.58°, p=0.04). In the coronal plane, greater joint movement was found in the trunk (4.0° vs. 3.19°, p=0.05). Gait Deviation Index was significantly higher while in ON condition vs. OFF condition (80.23° vs. 75.15°, p=0.06). Discussion: Although this study yields data that supports the fact that the deep brain stimulation of the subthalamic nucleus positively affects the gait characteristics studied and presented, there are others that have reported contradictory findings, possibly related to methodological limitations. Conclusions: Patients presented an improvement in gait kinematics and parameters with the effects of deep brain stimulation of the subthalamic nucleus. Gait Deviation Index was sensitive to changes observed under ON-OFF conditions. Studies with larger number of patients are needed to draw more accurate conclusions. http://www.revistaretos.org/index.php/retos/article/view/110243Deep brain stimulationParkinson’s diseaseGait analysiskinematics |
| spellingShingle | Juan F. Mier-García Lina M. Villegas-Trujillo Juan Camilo Salcedo Sebastián Ordoñez María José Uparela Fernanda Arbeláez Camilo A. Turriago-Pérez Lesbby Gómez-Salazar Óscar A. Escobar-Vidarte Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s disease Retos: Nuevas Tendencias en Educación Física, Deportes y Recreación Deep brain stimulation Parkinson’s disease Gait analysis kinematics |
| title | Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s disease |
| title_full | Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s disease |
| title_fullStr | Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s disease |
| title_full_unstemmed | Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s disease |
| title_short | Effect of subthalamic deep brain stimulation on gait in patients with advanced Parkinson’s disease |
| title_sort | effect of subthalamic deep brain stimulation on gait in patients with advanced parkinson s disease |
| topic | Deep brain stimulation Parkinson’s disease Gait analysis kinematics |
| url | http://www.revistaretos.org/index.php/retos/article/view/110243 |
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