Post-translational modifications as a key mechanism for herpes simplex virus type I evasion of host innate immunity

Post-translational modifications as a key mechanism for herpes simplex virus type I evasion of host innate immunity

Herpes simplex virus type 1 (HSV-1) is a DNA virus that infects humans and establishes long-term latency within the host. Throughout its prolonged interaction with the host, HSV-1 evades the innate immune system by encoding its own proteins. Post-translational modifications (PTMs) of these proteins...

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Bibliographic Details
Main Authors: Yongxing Zhang, Junlei Xie, Ying Feng, Abdul Qadeer, Shanni Li, Xu Deng, Lipeng Zhu, Bo Kong, Zanxian Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Microbiology
Subjects:
herpes simplex virus type 1
innate immunity
immune evasion
post-translational modifications
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1543676/full
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