HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives
Abstract The long non-coding RNA HOTAIR is overexpressed in many cancers and is associated with several cancer-promoting effects, including increased cell proliferation, migration and treatment resistance. HOTAIR levels correlate with tumor stage, lymph node metastasis and overall survival in patien...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Cancer Cell International |
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| Online Access: | https://doi.org/10.1186/s12935-024-03612-x |
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| author | Majid Nazari Emad Babakhanzadeh Arghavan Mollazadeh Mohadese Ahmadzade Elham Mohammadi Soleimani Elnaz Hajimaqsoudi |
| author_facet | Majid Nazari Emad Babakhanzadeh Arghavan Mollazadeh Mohadese Ahmadzade Elham Mohammadi Soleimani Elnaz Hajimaqsoudi |
| author_sort | Majid Nazari |
| collection | DOAJ |
| description | Abstract The long non-coding RNA HOTAIR is overexpressed in many cancers and is associated with several cancer-promoting effects, including increased cell proliferation, migration and treatment resistance. HOTAIR levels correlate with tumor stage, lymph node metastasis and overall survival in patients with various types of cancer. This highlights the potential uses of HOTAIR, including early cancer detection, predicting patient outcome, identifying high-risk individuals and assisting in therapy selection and monitoring. The aim of this review is to provide a comprehensive summary of the research progress, molecular mechanisms and clinical significance of HOTAIR in various human cancers. In addition, the clinical applications of HOTAIR, such as targeted therapy, radiotherapy, chemotherapy and immunotherapy, are discussed, and relevant information on the potential future advances of HOTAIR in cancer research is provided. |
| format | Article |
| id | doaj-art-954be2bf70a94680ad55ed987bfe8682 |
| institution | OA Journals |
| issn | 1475-2867 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj-art-954be2bf70a94680ad55ed987bfe86822025-08-20T01:57:12ZengBMCCancer Cell International1475-28672024-12-0124112610.1186/s12935-024-03612-xHOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectivesMajid Nazari0Emad Babakhanzadeh1Arghavan Mollazadeh2Mohadese Ahmadzade3Elham Mohammadi Soleimani4Elnaz Hajimaqsoudi5Department of Medical Genetics, Shahid Sadoughi University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Chemistry and Biochemistry, Northern Illinois UniversityDepartment of Urology, Shahid Beheshti University of Medical SciencesDepartment of Medical Microbiology, Kerman University of Medical ScienceDepartment of Medical Genetics, Shahid Sadoughi University of Medical SciencesAbstract The long non-coding RNA HOTAIR is overexpressed in many cancers and is associated with several cancer-promoting effects, including increased cell proliferation, migration and treatment resistance. HOTAIR levels correlate with tumor stage, lymph node metastasis and overall survival in patients with various types of cancer. This highlights the potential uses of HOTAIR, including early cancer detection, predicting patient outcome, identifying high-risk individuals and assisting in therapy selection and monitoring. The aim of this review is to provide a comprehensive summary of the research progress, molecular mechanisms and clinical significance of HOTAIR in various human cancers. In addition, the clinical applications of HOTAIR, such as targeted therapy, radiotherapy, chemotherapy and immunotherapy, are discussed, and relevant information on the potential future advances of HOTAIR in cancer research is provided.https://doi.org/10.1186/s12935-024-03612-xCancerHOTAIRBiomarkerChemotherapyImmunotherapyRadiotherapy |
| spellingShingle | Majid Nazari Emad Babakhanzadeh Arghavan Mollazadeh Mohadese Ahmadzade Elham Mohammadi Soleimani Elnaz Hajimaqsoudi HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives Cancer Cell International Cancer HOTAIR Biomarker Chemotherapy Immunotherapy Radiotherapy |
| title | HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives |
| title_full | HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives |
| title_fullStr | HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives |
| title_full_unstemmed | HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives |
| title_short | HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives |
| title_sort | hotair in cancer diagnostic prognostic and therapeutic perspectives |
| topic | Cancer HOTAIR Biomarker Chemotherapy Immunotherapy Radiotherapy |
| url | https://doi.org/10.1186/s12935-024-03612-x |
| work_keys_str_mv | AT majidnazari hotairincancerdiagnosticprognosticandtherapeuticperspectives AT emadbabakhanzadeh hotairincancerdiagnosticprognosticandtherapeuticperspectives AT arghavanmollazadeh hotairincancerdiagnosticprognosticandtherapeuticperspectives AT mohadeseahmadzade hotairincancerdiagnosticprognosticandtherapeuticperspectives AT elhammohammadisoleimani hotairincancerdiagnosticprognosticandtherapeuticperspectives AT elnazhajimaqsoudi hotairincancerdiagnosticprognosticandtherapeuticperspectives |