Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate Trihydrate
Under solvent-free conditions, different alcohols and phenols were efficiently acetylated at room temperature within short time periods by using acetic anhydride in the presence of catalytic quantities of sodium acetate trihydrate, which is a very inexpensive and mild reagent. Thiols were also shown...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/642479 |
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| author | Mohammad M. Mojtahedi Shamim Samadian |
| author_facet | Mohammad M. Mojtahedi Shamim Samadian |
| author_sort | Mohammad M. Mojtahedi |
| collection | DOAJ |
| description | Under solvent-free conditions, different alcohols and phenols were efficiently acetylated at room temperature within short time periods by using acetic anhydride in the presence of catalytic quantities of sodium acetate trihydrate, which is a very inexpensive and mild reagent. Thiols were also shown to behave equally well under the same conditions. Chemoselective protection of less hindered alcohols in the presence of bulkier homologues and phenols in the presence of alcohols was achieved using competitive experiments. |
| format | Article |
| id | doaj-art-9541e59c818b43e0bdf22d634c95099d |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-9541e59c818b43e0bdf22d634c95099d2025-02-03T01:25:28ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/642479642479Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate TrihydrateMohammad M. Mojtahedi0Shamim Samadian1Department of Organic Chemistry and Natural Products, Chemistry and Chemical Engineering Research Center of Iran, Pajouhesh Boulevard, 17th Km Tehran-Karaj Highway, P.O. Box 14335-186, Tehran 14968-13151, IranDepartment of Organic Chemistry and Natural Products, Chemistry and Chemical Engineering Research Center of Iran, Pajouhesh Boulevard, 17th Km Tehran-Karaj Highway, P.O. Box 14335-186, Tehran 14968-13151, IranUnder solvent-free conditions, different alcohols and phenols were efficiently acetylated at room temperature within short time periods by using acetic anhydride in the presence of catalytic quantities of sodium acetate trihydrate, which is a very inexpensive and mild reagent. Thiols were also shown to behave equally well under the same conditions. Chemoselective protection of less hindered alcohols in the presence of bulkier homologues and phenols in the presence of alcohols was achieved using competitive experiments.http://dx.doi.org/10.1155/2013/642479 |
| spellingShingle | Mohammad M. Mojtahedi Shamim Samadian Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate Trihydrate Journal of Chemistry |
| title | Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate Trihydrate |
| title_full | Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate Trihydrate |
| title_fullStr | Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate Trihydrate |
| title_full_unstemmed | Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate Trihydrate |
| title_short | Efficient and Rapid Solvent-Free Acetylation of Alcohols, Phenols, and Thiols Using Catalytic Amounts of Sodium Acetate Trihydrate |
| title_sort | efficient and rapid solvent free acetylation of alcohols phenols and thiols using catalytic amounts of sodium acetate trihydrate |
| url | http://dx.doi.org/10.1155/2013/642479 |
| work_keys_str_mv | AT mohammadmmojtahedi efficientandrapidsolventfreeacetylationofalcoholsphenolsandthiolsusingcatalyticamountsofsodiumacetatetrihydrate AT shamimsamadian efficientandrapidsolventfreeacetylationofalcoholsphenolsandthiolsusingcatalyticamountsofsodiumacetatetrihydrate |