GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development

GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development

Introduction: Osteoarthritis (OA) is the most common arthritis that is characterized by the progressive synovial inflammation and loss of articular cartilage. Although GYY4137 is a novel and slow-releasing hydrogen sulfide (H2S) donor with potent anti-inflammatory properties that may modulate the pr...

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Main Authors: Jun Ma, Peng Yang, Zhibin Zhou, Tengfei Song, Liang Jia, Xiaofei Ye, Wei Yan, Jiuyi Sun, Tianwen Ye, Lei Zhu
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Advanced Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224002236
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