EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion

EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion

Background Epstein-Barr virus (EBV) is a double-stranded DNA oncogenic virus. Several types of solid tumors, such as nasopharyngeal carcinoma, EBV-associated gastric carcinoma, and lymphoepithelioma-like carcinoma of the lung, have been linked to EBV infection. Currently, several TCR-T-cell therapie...

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Main Authors: Yuanyuan Chen, Yan Wang, Jia He, Song Li, Jingjing Zhao, Hao Chen, Yan Tang, Jian-Chuan Xia, Yan Ren, Tong Xiang, Qiuzhong Pan, Desheng Weng, Dijun Ouyang, Xinyi Yang, Qijing Wang, Yongqiang Li, Jin-Qi You, Yingzi Li, Chi Xu, Sisi Xie, Jiamin Lian
Format: Article
Language:English
Published: BMJ Publishing Group 2024-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/6/e008375.full
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