In vitro and in silico evaluation of synthetic compounds derived from bi-triazoles against asexual and sexual forms of Plasmodium falciparum

In vitro and in silico evaluation of synthetic compounds derived from bi-triazoles against asexual and sexual forms of Plasmodium falciparum

Abstract Background Despite advances in malaria chemotherapy, the disease continues to claim thousands of lives annually. Addressing this issue requires the discovery of new compounds to counteract resistance threatening the current therapeutic arsenal. In this context, bi-triazoles are substances w...

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Main Authors: Leandro do Nascimento Martinez, Minelly Azevedo da Silva, Saara Neri Fialho, Marcinete Latorre Almeida, Amália dos Santos Ferreira, Aurileya de Jesus Gouveia, Welington da Silva Paula do Nascimento, Ana Paula de Azevedo dos Santos, Norton Rubens Diunior Lucas Pejara Rossi, Jansen Fernandes de Medeiros, Natalie Ferreira Araújo, Quelli Larissa Oliveira de Santana, Carlos Roland Kaiser, Sabrina Baptista Ferreira, Maisa da Silva Araujo, Carolina Bioni Garcia Teles
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Malaria Journal
Subjects:
Bi-triazoles
Gametocytes
Transmission blocking
Plasmodium falciparum
In silico
Online Access:https://doi.org/10.1186/s12936-025-05297-7
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