CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers
CHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized for its significant roles in these cellular processes and its impact on various human diseases and cancers. This review aims to provide a comprehensive overview of CHAC1’s molecular functions, regulatory me...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1458716/full |
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| author | Jiasen Sun Hui Ren Jiawen Wang Xiang Xiao Lin Zhu Yanyan Wang Lili Yang |
| author_facet | Jiasen Sun Hui Ren Jiawen Wang Xiang Xiao Lin Zhu Yanyan Wang Lili Yang |
| author_sort | Jiasen Sun |
| collection | DOAJ |
| description | CHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized for its significant roles in these cellular processes and its impact on various human diseases and cancers. This review aims to provide a comprehensive overview of CHAC1’s molecular functions, regulatory mechanisms, and effects in different pathological contexts. Specifically, the study objectives are to elucidate the biochemical pathways involving CHAC1, explore its regulatory network, and discuss its implications in disease progression and potential therapeutic strategies. As a γ-glutamyl cyclotransferase, CHAC1 degrades glutathione, affecting calcium signaling and mitochondrial function. Its regulation involves transcription factors like ATF4 and ATF3, which control CHAC1 mRNA expression. CHAC1 is crucial for maintaining redox balance and regulating cell death pathways in cancer. Its elevated levels are associated with poor prognosis in many cancers, indicating its potential as a biomarker and therapeutic target. Additionally, CHAC1 influences non-cancerous diseases such as neurodegenerative and cardiovascular disorders. Therapeutically, targeting CHAC1 could increase cancer cell sensitivity to ferroptosis, aiding in overcoming resistance to standard treatments. This review compiles current knowledge and recent discoveries, emphasizing CHAC1’s vital role in human diseases and its potential in diagnostic and therapeutic applications. |
| format | Article |
| id | doaj-art-95372f6df46749cfa18a2044e1c3bfad |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-95372f6df46749cfa18a2044e1c3bfad2025-08-20T02:12:10ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-10-011210.3389/fcell.2024.14587161458716CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancersJiasen Sun0Hui Ren1Jiawen Wang2Xiang Xiao3Lin Zhu4Yanyan Wang5Lili Yang6Department of Gastroenterology, Ankang Central Hospital, Ankang, Shaanxi, ChinaDepartment of Cardiovascular Disease, Ankang Central Hospital, Ankang, Shaanxi, ChinaDepartment of Cardiovascular Disease, Ankang Central Hospital, Ankang, Shaanxi, ChinaDepartment of Gastroenterology, Ankang Central Hospital, Ankang, Shaanxi, ChinaDepartment of Cardiovascular Disease, Ankang Central Hospital, Ankang, Shaanxi, ChinaDepartment of Cardiovascular Disease, Ankang Central Hospital, Ankang, Shaanxi, ChinaDepartment of Cardiovascular Disease, Ankang Central Hospital, Ankang, Shaanxi, ChinaCHAC1, an essential regulator of oxidative stress and ferroptosis, is increasingly recognized for its significant roles in these cellular processes and its impact on various human diseases and cancers. This review aims to provide a comprehensive overview of CHAC1’s molecular functions, regulatory mechanisms, and effects in different pathological contexts. Specifically, the study objectives are to elucidate the biochemical pathways involving CHAC1, explore its regulatory network, and discuss its implications in disease progression and potential therapeutic strategies. As a γ-glutamyl cyclotransferase, CHAC1 degrades glutathione, affecting calcium signaling and mitochondrial function. Its regulation involves transcription factors like ATF4 and ATF3, which control CHAC1 mRNA expression. CHAC1 is crucial for maintaining redox balance and regulating cell death pathways in cancer. Its elevated levels are associated with poor prognosis in many cancers, indicating its potential as a biomarker and therapeutic target. Additionally, CHAC1 influences non-cancerous diseases such as neurodegenerative and cardiovascular disorders. Therapeutically, targeting CHAC1 could increase cancer cell sensitivity to ferroptosis, aiding in overcoming resistance to standard treatments. This review compiles current knowledge and recent discoveries, emphasizing CHAC1’s vital role in human diseases and its potential in diagnostic and therapeutic applications.https://www.frontiersin.org/articles/10.3389/fcell.2024.1458716/fullferroptosiscell deathunfold protein responseendoplasmic reticulum stresscancerglutathione |
| spellingShingle | Jiasen Sun Hui Ren Jiawen Wang Xiang Xiao Lin Zhu Yanyan Wang Lili Yang CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers Frontiers in Cell and Developmental Biology ferroptosis cell death unfold protein response endoplasmic reticulum stress cancer glutathione |
| title | CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers |
| title_full | CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers |
| title_fullStr | CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers |
| title_full_unstemmed | CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers |
| title_short | CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers |
| title_sort | chac1 a master regulator of oxidative stress and ferroptosis in human diseases and cancers |
| topic | ferroptosis cell death unfold protein response endoplasmic reticulum stress cancer glutathione |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1458716/full |
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