Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study
Aim: to determine the role of serum lactate and diabetic ketoacidosis (DKA) severity as predictors for five-days mortality in DKA patients. Methods: a prospective cohort study was conducted in DKA patients admitted to emergency department (ED) at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, dur...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Interna Publishing
2014-01-01
|
| Series: | Acta Medica Indonesiana |
| Online Access: | http://actamedindones.org/index.php/ijim/article/view/59 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849392254547918848 |
|---|---|
| author | Suhendro Suwarto Bambang Sutrisna Sarwono Waspadji Herdiman T Pohan |
| author_facet | Suhendro Suwarto Bambang Sutrisna Sarwono Waspadji Herdiman T Pohan |
| author_sort | Suhendro Suwarto |
| collection | DOAJ |
| description |
Aim: to determine the role of serum lactate and diabetic ketoacidosis (DKA) severity as predictors for five-days mortality in DKA patients. Methods: a prospective cohort study was conducted in DKA patients admitted to emergency department (ED) at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, during 2007-2008 periods. Predictors for 5 days mortality in DKA patients in this study including serum lactate and DKA severity (plasma glucose, arterial blood pH, serum bicarbonate, osmolality, anion gap, and alteration in sensorium) at admission. Cox’s Proportional Hazard Regression Analysis was used to determine independent predictors for 5-days mortality among study population. Results: sixty patients with diabetic ketoacidosis were enrolled in the study; in which 24 (40%) patients were died within 5 days after admission. In the multivariate analysis, the lactate level ≥4 mmol/L (HR, 3.09; 95% CI, 1.36-7.05) and altered in sensorium stuporous/comatose (HR, 3.38; 95% CI, 1.45-7.87) were identified as independent predictors for 5-days mortality in DKA adult patients. Conclusion: lactate level ≥4 mmol/L and altered in sensorium stuporous/comatose can be used to predict 5-days mortality in adult patients with DKA.
Key words: diabetic ketoacidosis, sepsis, lactate level, alteration in sensorium mortality.
|
| format | Article |
| id | doaj-art-95365178355e448ea33fa79ebb680d1b |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-95365178355e448ea33fa79ebb680d1b2025-08-20T03:40:48ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322014-01-01461Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort StudySuhendro Suwarto0Bambang Sutrisna1Sarwono Waspadji2Herdiman T Pohan3Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Epidemiology, Faculty of Public Health Universitas IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia Aim: to determine the role of serum lactate and diabetic ketoacidosis (DKA) severity as predictors for five-days mortality in DKA patients. Methods: a prospective cohort study was conducted in DKA patients admitted to emergency department (ED) at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, during 2007-2008 periods. Predictors for 5 days mortality in DKA patients in this study including serum lactate and DKA severity (plasma glucose, arterial blood pH, serum bicarbonate, osmolality, anion gap, and alteration in sensorium) at admission. Cox’s Proportional Hazard Regression Analysis was used to determine independent predictors for 5-days mortality among study population. Results: sixty patients with diabetic ketoacidosis were enrolled in the study; in which 24 (40%) patients were died within 5 days after admission. In the multivariate analysis, the lactate level ≥4 mmol/L (HR, 3.09; 95% CI, 1.36-7.05) and altered in sensorium stuporous/comatose (HR, 3.38; 95% CI, 1.45-7.87) were identified as independent predictors for 5-days mortality in DKA adult patients. Conclusion: lactate level ≥4 mmol/L and altered in sensorium stuporous/comatose can be used to predict 5-days mortality in adult patients with DKA. Key words: diabetic ketoacidosis, sepsis, lactate level, alteration in sensorium mortality. http://actamedindones.org/index.php/ijim/article/view/59 |
| spellingShingle | Suhendro Suwarto Bambang Sutrisna Sarwono Waspadji Herdiman T Pohan Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study Acta Medica Indonesiana |
| title | Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study |
| title_full | Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study |
| title_fullStr | Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study |
| title_full_unstemmed | Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study |
| title_short | Predictors of Five Days Mortality in Diabetic Ketoacidosis Patients: a Prospective Cohort Study |
| title_sort | predictors of five days mortality in diabetic ketoacidosis patients a prospective cohort study |
| url | http://actamedindones.org/index.php/ijim/article/view/59 |
| work_keys_str_mv | AT suhendrosuwarto predictorsoffivedaysmortalityindiabeticketoacidosispatientsaprospectivecohortstudy AT bambangsutrisna predictorsoffivedaysmortalityindiabeticketoacidosispatientsaprospectivecohortstudy AT sarwonowaspadji predictorsoffivedaysmortalityindiabeticketoacidosispatientsaprospectivecohortstudy AT herdimantpohan predictorsoffivedaysmortalityindiabeticketoacidosispatientsaprospectivecohortstudy |