Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic Review
Aims: Treatment-resistant depression (TRD), defined as failure to achieve remission despite adequate antidepressant trials, remains a pervasive clinical conundrum, linked to reduced quality of life, increased mortality, and higher healthcare costs. Pharmacogenomics-guided treatment (PGT) offers a po...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2025-06-01
|
| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472425101919/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850059304151810048 |
|---|---|
| author | Leah Rose Alexander |
| author_facet | Leah Rose Alexander |
| author_sort | Leah Rose Alexander |
| collection | DOAJ |
| description | Aims: Treatment-resistant depression (TRD), defined as failure to achieve remission despite adequate antidepressant trials, remains a pervasive clinical conundrum, linked to reduced quality of life, increased mortality, and higher healthcare costs. Pharmacogenomics-guided treatment (PGT) offers a potential solution to the ongoing challenge of TRD by using genomic testing to identify genetic factors influencing drug metabolism and response. This systematic review aimed to assess whether PGT improves symptom remission in adults with TRD compared with treatment as usual (TAU). Secondary objectives included evaluating the impact of PGT on treatment response and overall symptom improvement. |
| format | Article |
| id | doaj-art-9534b66e7ea14683869cef7ba6ebc4f6 |
| institution | DOAJ |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-9534b66e7ea14683869cef7ba6ebc4f62025-08-20T02:50:55ZengCambridge University PressBJPsych Open2056-47242025-06-0111S19S1910.1192/bjo.2025.10191Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic ReviewLeah Rose Alexander0University of Buckingham Medical School, Buckingham, United KingdomAims: Treatment-resistant depression (TRD), defined as failure to achieve remission despite adequate antidepressant trials, remains a pervasive clinical conundrum, linked to reduced quality of life, increased mortality, and higher healthcare costs. Pharmacogenomics-guided treatment (PGT) offers a potential solution to the ongoing challenge of TRD by using genomic testing to identify genetic factors influencing drug metabolism and response. This systematic review aimed to assess whether PGT improves symptom remission in adults with TRD compared with treatment as usual (TAU). Secondary objectives included evaluating the impact of PGT on treatment response and overall symptom improvement.https://www.cambridge.org/core/product/identifier/S2056472425101919/type/journal_article |
| spellingShingle | Leah Rose Alexander Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic Review BJPsych Open |
| title | Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic Review |
| title_full | Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic Review |
| title_fullStr | Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic Review |
| title_full_unstemmed | Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic Review |
| title_short | Pharmacogenomics-Guided Antidepressant Therapy as a Solution to Treatment-Resistant Depression: A Systematic Review |
| title_sort | pharmacogenomics guided antidepressant therapy as a solution to treatment resistant depression a systematic review |
| url | https://www.cambridge.org/core/product/identifier/S2056472425101919/type/journal_article |
| work_keys_str_mv | AT leahrosealexander pharmacogenomicsguidedantidepressanttherapyasasolutiontotreatmentresistantdepressionasystematicreview |