Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease
Background: Increasing evidence has documented cortical involvement at all stages of PD. The local vulnerabilities within certain brain regions in PD have been previously demonstrated, whereas its underlying genetic and neurochemical factors remain unclear. This study aims to investigate the spatial...
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000346 |
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| author | Su Yan Jun Lu Bingfang Duan Hongquan Zhu Tian Tian Yuanyuan Qin Yuanhao Li Wenzhen Zhu |
| author_facet | Su Yan Jun Lu Bingfang Duan Hongquan Zhu Tian Tian Yuanyuan Qin Yuanhao Li Wenzhen Zhu |
| author_sort | Su Yan |
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| description | Background: Increasing evidence has documented cortical involvement at all stages of PD. The local vulnerabilities within certain brain regions in PD have been previously demonstrated, whereas its underlying genetic and neurochemical factors remain unclear. This study aims to investigate the spatial spectrum of cortical atrophy in Parkinson’s disease (PD) and link these variances in gray matter properties and curvature respectively to putative molecular pathways and neurotransmitter factors. Methods: We recruited 141 clinically diagnosed PD patients and 70 healthy controls. Cortical morphological abnormalities of PD were obtained by intergroup comparisons in gray matter properties metrics and curvature measurements. Then we performed gene-category enrichment and spatial correlation analyses to evaluate the specific correspondence between cortical alteration in PD and genetic expression from the Allen Human Brain Atlas and normative neurotransmitter atlases from Neuromaps. Results: We found decreased gray matter properties in temporal, somatomotor, cingulate and occipital cortices, decreased curvature measures in occipital, temporal and orbitofrontal cortices, and increased curvature measures in somatomotor, prefrontal and posterior parietal cortices for PD patients. The related genes were enriched for the glucose metabolism, mitochondrial function, and post-translational histone modifications processes. In addition, the serotonin and norepinephrine transporter devoted more to gray matter properties alterations while the dopamine, gamma-aminobutyric acid receptors, and norepinephrine transporter were strong contributors of curvature abnormalities in PD. Conclusions: Collectively, the present study offered interpretation of cortical morphological alterations and the cortical pathogenic theory in PD from genetic and neurochemical perspectives, which inspire further research on new pharmacotherapeutic approaches. |
| format | Article |
| id | doaj-art-953168acbde14003b3af318ff3d55514 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-953168acbde14003b3af318ff3d555142025-02-07T04:46:47ZengElsevierBrain Research Bulletin1873-27472025-02-01221111222Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s diseaseSu Yan0Jun Lu1Bingfang Duan2Hongquan Zhu3Tian Tian4Yuanyuan Qin5Yuanhao Li6Wenzhen Zhu7Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of CT & MRI, The First Affiliated Hospital, College of Medicine, Shihezi University, 107 North Second Road, Shihezi, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Correspondence to: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, Wuhan 430030, China.Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Correspondence to: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, Wuhan 430030, China.Background: Increasing evidence has documented cortical involvement at all stages of PD. The local vulnerabilities within certain brain regions in PD have been previously demonstrated, whereas its underlying genetic and neurochemical factors remain unclear. This study aims to investigate the spatial spectrum of cortical atrophy in Parkinson’s disease (PD) and link these variances in gray matter properties and curvature respectively to putative molecular pathways and neurotransmitter factors. Methods: We recruited 141 clinically diagnosed PD patients and 70 healthy controls. Cortical morphological abnormalities of PD were obtained by intergroup comparisons in gray matter properties metrics and curvature measurements. Then we performed gene-category enrichment and spatial correlation analyses to evaluate the specific correspondence between cortical alteration in PD and genetic expression from the Allen Human Brain Atlas and normative neurotransmitter atlases from Neuromaps. Results: We found decreased gray matter properties in temporal, somatomotor, cingulate and occipital cortices, decreased curvature measures in occipital, temporal and orbitofrontal cortices, and increased curvature measures in somatomotor, prefrontal and posterior parietal cortices for PD patients. The related genes were enriched for the glucose metabolism, mitochondrial function, and post-translational histone modifications processes. In addition, the serotonin and norepinephrine transporter devoted more to gray matter properties alterations while the dopamine, gamma-aminobutyric acid receptors, and norepinephrine transporter were strong contributors of curvature abnormalities in PD. Conclusions: Collectively, the present study offered interpretation of cortical morphological alterations and the cortical pathogenic theory in PD from genetic and neurochemical perspectives, which inspire further research on new pharmacotherapeutic approaches.http://www.sciencedirect.com/science/article/pii/S0361923025000346Cortical morphologyNeurotransmitter systemGene expressionParkinson’s disease |
| spellingShingle | Su Yan Jun Lu Bingfang Duan Hongquan Zhu Tian Tian Yuanyuan Qin Yuanhao Li Wenzhen Zhu Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease Brain Research Bulletin Cortical morphology Neurotransmitter system Gene expression Parkinson’s disease |
| title | Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease |
| title_full | Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease |
| title_fullStr | Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease |
| title_full_unstemmed | Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease |
| title_short | Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease |
| title_sort | genetic and neurochemical profiles underlying cortical morphometric vulnerability to parkinson s disease |
| topic | Cortical morphology Neurotransmitter system Gene expression Parkinson’s disease |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000346 |
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