Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging
The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8882207 |
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| author | Tania Alexandra Couto Shiyang Xu Paulo Armada da Silva Chenggang Wu Karl Neergaard Meng-Yun Wang Juan Zhang Yutao Xiang Zhen Yuan |
| author_facet | Tania Alexandra Couto Shiyang Xu Paulo Armada da Silva Chenggang Wu Karl Neergaard Meng-Yun Wang Juan Zhang Yutao Xiang Zhen Yuan |
| author_sort | Tania Alexandra Couto |
| collection | DOAJ |
| description | The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during figurative language comprehension. The method is aimed at mapping significant causal relationships across language brain networks, captured by functional near-infrared spectroscopy measurements (fNIRS): (i) definition of regions of interest (ROIs) based on significant channels extracted from spatial activation maps; (ii) inspection of significant causal relationships in temporal resolution, exploring the experimental task agreement; and (iii) early identification of stronger causal relationships that guide neuromodulation intervention, targeting impaired connectivity pathways. Our results propose top-down mechanisms responsible for perceptive-attention engagement in the left anterior frontal cortex and bottom-up mechanism in the right hemispheres during the semantic integration of figurative language. Moreover, the interhemispheric directional flow suggests a right hemisphere engagement in decoding unfamiliar literal sentences and fine-grained integration guided by the left hemisphere to reduce ambiguity in meaningless words. Finally, bottom-up mechanisms seem activated by logographic-semantic processing in literal meanings and memory storage centres in meaningless comprehension. To sum up, our main findings reveal that the Granger Prediction Estimation (GPE) integrated strategy proposes an effective link between assessment and intervention, capable of enhancing the efficiency of the treatment in language disorders and reducing the neuromodulation side effects. |
| format | Article |
| id | doaj-art-952eb3359e0c401ca5cc3feecedae14b |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-952eb3359e0c401ca5cc3feecedae14b2025-02-03T06:00:48ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88822078882207Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical NeuroimagingTania Alexandra Couto0Shiyang Xu1Paulo Armada da Silva2Chenggang Wu3Karl Neergaard4Meng-Yun Wang5Juan Zhang6Yutao Xiang7Zhen Yuan8Centre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaFaculty of Human Kinetics, University of Lisbon, Lisbon, PortugalCentre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macau S.A.R., ChinaThe current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during figurative language comprehension. The method is aimed at mapping significant causal relationships across language brain networks, captured by functional near-infrared spectroscopy measurements (fNIRS): (i) definition of regions of interest (ROIs) based on significant channels extracted from spatial activation maps; (ii) inspection of significant causal relationships in temporal resolution, exploring the experimental task agreement; and (iii) early identification of stronger causal relationships that guide neuromodulation intervention, targeting impaired connectivity pathways. Our results propose top-down mechanisms responsible for perceptive-attention engagement in the left anterior frontal cortex and bottom-up mechanism in the right hemispheres during the semantic integration of figurative language. Moreover, the interhemispheric directional flow suggests a right hemisphere engagement in decoding unfamiliar literal sentences and fine-grained integration guided by the left hemisphere to reduce ambiguity in meaningless words. Finally, bottom-up mechanisms seem activated by logographic-semantic processing in literal meanings and memory storage centres in meaningless comprehension. To sum up, our main findings reveal that the Granger Prediction Estimation (GPE) integrated strategy proposes an effective link between assessment and intervention, capable of enhancing the efficiency of the treatment in language disorders and reducing the neuromodulation side effects.http://dx.doi.org/10.1155/2020/8882207 |
| spellingShingle | Tania Alexandra Couto Shiyang Xu Paulo Armada da Silva Chenggang Wu Karl Neergaard Meng-Yun Wang Juan Zhang Yutao Xiang Zhen Yuan Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging Neural Plasticity |
| title | Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging |
| title_full | Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging |
| title_fullStr | Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging |
| title_full_unstemmed | Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging |
| title_short | Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging |
| title_sort | effective connectivity study guiding the neuromodulation intervention in figurative language comprehension using optical neuroimaging |
| url | http://dx.doi.org/10.1155/2020/8882207 |
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