Disseminated crusted papules in a newborn
Background. Congenital self-healing Langerhans cell histiocytosis (Hashimoto-Pritzker disease) is the rarest form of Langerhans cell histiocytosis, usually confined to the skin and/or mucous membranes. Cutaneous eruption is mostly generalized, papular, nodular or vesicular. Despite impressive clinic...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2006-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500607681P.pdf |
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| author | Pavlović Miloš D. Minić Aleksandra Zolotarevski Lidija Vesić Sonja |
| author_facet | Pavlović Miloš D. Minić Aleksandra Zolotarevski Lidija Vesić Sonja |
| author_sort | Pavlović Miloš D. |
| collection | DOAJ |
| description | Background. Congenital self-healing Langerhans cell histiocytosis (Hashimoto-Pritzker disease) is the rarest form of Langerhans cell histiocytosis, usually confined to the skin and/or mucous membranes. Cutaneous eruption is mostly generalized, papular, nodular or vesicular. Despite impressive clinical presentation in a newborn it infrequently spreads to internal organs (which then portends a grave prognosis, indistinguishable from Letterer-Siwe disease). Case report. We presented a full-term newborn, female, 3.3 kg who had a multitude of erythematous and crusted papules, nodules and pseudovesicles distributed all over the body, except for the mucous membranes. A biopsy and haematoxylin − eosin stain revealed dermal infiltration of pleomorphic histiocytes with eosinophilic ground-glass cytoplasm and round to bean-shaped nuclei. Over the next six weeks the eruption gradually subsided leaving no residues, or a few atrophic scars. Conclusion. There is no need for specific treatment of congenital self-healing Langerhans cell-histiocytosis in the absence of multiorgan involvement. However, a close and regular follow-up is necessary to evaluate the children for systemic symptoms and signs. |
| format | Article |
| id | doaj-art-952ae7aa0e9e40d2962cfe3bf150bbfe |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-952ae7aa0e9e40d2962cfe3bf150bbfe2025-08-20T03:37:01ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502006-01-0163768168310.2298/VSP0607681PDisseminated crusted papules in a newbornPavlović Miloš D.Minić AleksandraZolotarevski LidijaVesić SonjaBackground. Congenital self-healing Langerhans cell histiocytosis (Hashimoto-Pritzker disease) is the rarest form of Langerhans cell histiocytosis, usually confined to the skin and/or mucous membranes. Cutaneous eruption is mostly generalized, papular, nodular or vesicular. Despite impressive clinical presentation in a newborn it infrequently spreads to internal organs (which then portends a grave prognosis, indistinguishable from Letterer-Siwe disease). Case report. We presented a full-term newborn, female, 3.3 kg who had a multitude of erythematous and crusted papules, nodules and pseudovesicles distributed all over the body, except for the mucous membranes. A biopsy and haematoxylin − eosin stain revealed dermal infiltration of pleomorphic histiocytes with eosinophilic ground-glass cytoplasm and round to bean-shaped nuclei. Over the next six weeks the eruption gradually subsided leaving no residues, or a few atrophic scars. Conclusion. There is no need for specific treatment of congenital self-healing Langerhans cell-histiocytosis in the absence of multiorgan involvement. However, a close and regular follow-up is necessary to evaluate the children for systemic symptoms and signs.http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500607681P.pdfhistiocytosislangerhans-cellinfantnewbornexanthema |
| spellingShingle | Pavlović Miloš D. Minić Aleksandra Zolotarevski Lidija Vesić Sonja Disseminated crusted papules in a newborn Vojnosanitetski Pregled histiocytosis langerhans-cell infant newborn exanthema |
| title | Disseminated crusted papules in a newborn |
| title_full | Disseminated crusted papules in a newborn |
| title_fullStr | Disseminated crusted papules in a newborn |
| title_full_unstemmed | Disseminated crusted papules in a newborn |
| title_short | Disseminated crusted papules in a newborn |
| title_sort | disseminated crusted papules in a newborn |
| topic | histiocytosis langerhans-cell infant newborn exanthema |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2006/0042-84500607681P.pdf |
| work_keys_str_mv | AT pavlovicmilosd disseminatedcrustedpapulesinanewborn AT minicaleksandra disseminatedcrustedpapulesinanewborn AT zolotarevskilidija disseminatedcrustedpapulesinanewborn AT vesicsonja disseminatedcrustedpapulesinanewborn |