The kidney injury biomarker profile of patients with lupus nephritis remains unchanged with the second-generation calcineurin inhibitor voclosporin

The kidney injury biomarker profile of patients with lupus nephritis remains unchanged with the second-generation calcineurin inhibitor voclosporin

ObjectivesKidney injury in patients with lupus nephritis (LN) results in pro-fibrotic biomarker expression, a manifestation also observed with calcineurin inhibitor (CNI) therapy. The second-generation CNI, voclosporin, is approved in the United States and Europe for the treatment of patients with a...

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Bibliographic Details
Main Authors: Biff F. Palmer, James A. Tumlin, Jai Radhakrishnan, Linda M. Rehaume, Jennifer L. Cross, Robert B. Huizinga
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Nephrology
Subjects:
lupus nephritis
voclosporin
biomarker
nephrotoxicity
calcineurin inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fneph.2025.1540471/full
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